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  Oscillatory stimuli differentiate adapting circuit topologies

Rahi, S. J., Larsch, J., Pecani, K., Katsov, A. Y., Mansouri, N., Tsaneva-Atanasova, K., et al. (2017). Oscillatory stimuli differentiate adapting circuit topologies. Nature methods, 14(10), 1010-1016. doi:10.1038/NMETH.4408.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-0AC7-A Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-0AC8-8
Genre: Journal Article

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 Creators:
Rahi, Sahand Jamal1, Author
Larsch, Johannes2, Author              
Pecani, Kresti1, Author
Katsov, Alexander Y.1, Author
Mansouri, Nahal1, Author
Tsaneva-Atanasova, Krasimira1, Author
Sontag, Eduardo D.1, Author
Cross, Frederick R.1, Author
Affiliations:
1external, ou_persistent22              
2Department: Genes-Circuits-Behavior / Baier, MPI of Neurobiology, Max Planck Society, ou_1128545              

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Free keywords: CELL-CYCLE TRANSCRIPTION; FOLD-CHANGE DETECTION; CAENORHABDITIS-ELEGANS; BACTERIAL CHEMOTAXIS; SIGNAL-TRANSDUCTION; PERFECT ADAPTATION; POSITIVE-FEEDBACK; C-ELEGANS; NETWORK; PATHWAYSBiochemistry & Molecular Biology;
 Abstract: Biology emerges from interactions between molecules, which are challenging to elucidate with current techniques. An orthogonal approach is to probe for 'response signatures' that identify specific circuit motifs. For example, bistability, hysteresis, or irreversibility are used to detect positive feedback loops. For adapting systems, such signatures are not known. Only two circuit motifs generate adaptation: negative feedback loops (NFLs) and incoherent feed-forward loops (IFFLs). On the basis of computational testing and mathematical proofs, we propose differential signatures: in response to oscillatory stimulation, NFLs but not IFFLs show refractory-period stabilization (robustness to changes in stimulus duration) or period skipping. Applying this approach to yeast, we identified the circuit dominating cell cycle timing. In Caenorhabditis elegans AWA neurons, which are crucial for chemotaxis, we uncovered a Ca2+ NFL leading to adaptation that would be difficult to find by other means. These response signatures allow direct access to the outlines of the wiring diagrams of adapting systems.

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Language(s): eng - English
 Dates: 2017-08-282017-10
 Publication Status: Published in print
 Pages: 11
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: ISI: 000412002700024
DOI: 10.1038/NMETH.4408
 Degree: -

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Title: Nature methods
  Other : Nature methods
Source Genre: Journal
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Publ. Info: New York, NY : Nature Pub. Group
Pages: - Volume / Issue: 14 (10) Sequence Number: - Start / End Page: 1010 - 1016 Identifier: ISSN: 1548-7091
CoNE: /journals/resource/111088195279556