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  Central amygdala circuits modulate food consumption through a positive-valence mechanism

Douglass, A. M., Kucukdereli, H., Ponserre, M., Markovic, M., Gruendemann, J., Strobel, C., et al. (2017). Central amygdala circuits modulate food consumption through a positive-valence mechanism. Nature Neuroscience, 20(10), 1384-1394. doi:10.1038/nn.4623.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-0AF4-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-0AF5-2
Genre: Journal Article

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 Creators:
Douglass, Amelia M.1, Author              
Kucukdereli, Hakan1, Author              
Ponserre, Marion1, Author              
Markovic, Milica2, Author
Gruendemann, Jan2, Author
Strobel, Cornelia1, Author              
Alcala Morales, Pilar L.1, Author              
Conzelmann, Karl-Klaus2, Author
Luethi, Andreas2, Author
Klein, Rüdiger1, Author              
Affiliations:
1Department: Molecules-Signaling-Development / Klein, MPI of Neurobiology, Max Planck Society, ou_1113546              
2external, ou_persistent22              

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Free keywords: CONSUMMATORY BEHAVIORS; LATERAL HYPOTHALAMUS; DOPAMINERGIC-NEURONS; INCENTIVE SALIENCE; LITHIUM-CHLORIDE; CONDITIONED FEAR; RAT-BRAIN; REWARD; ACTIVATION; LIPOPOLYSACCHARIDENeurosciences & Neurology;
 Abstract: The complex behaviors underlying reward seeking and consumption are integral to organism survival. The hypothalamus and mesolimbic dopamine system are key mediators of these behaviors, yet regulation of appetitive and consummatory behaviors outside of these regions is poorly understood. The central nucleus of the amygdala (CeA) has been implicated in feeding and reward, but the neurons and circuit mechanisms that positively regulate these behaviors remain unclear. Here, we defined the neuronal mechanisms by which CeA neurons promote food consumption. Using in vivo activity manipulations and Ca2+ imaging in mice, we found that GABAergic serotonin receptor 2a (Htr2a)-expressing CeA neurons modulate food consumption, promote positive reinforcement and are active in vivo during eating. We demonstrated electrophysiologically, anatomically and behaviorally that intra-CeA and long-range circuit mechanisms underlie these behaviors. Finally, we showed that CeA(Htr2a) neurons receive inputs from feeding-relevant brain regions. Our results illustrate how defined CeA neural circuits positively regulate food consumption.

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Language(s): eng - English
 Dates: 2017-08-212017-10
 Publication Status: Published in print
 Pages: 19
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: ISI: 000411686400012
DOI: 10.1038/nn.4623
 Degree: -

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Title: Nature Neuroscience
  Other : Nat. Neurosci.
Source Genre: Journal
 Creator(s):
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Publ. Info: New York, NY : Nature America Inc.
Pages: - Volume / Issue: 20 (10) Sequence Number: - Start / End Page: 1384 - 1394 Identifier: ISSN: 1097-6256
CoNE: /journals/resource/954925610931