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  The Eukaryotic CO2-Concentrating Organelle Is Liquid-like and Exhibits Dynamic Reorganization

Freeman Rosenzweig, E. S., Xu, B., Kuhn Cuellar, L., Martinez-Sanchez, A., Schaffer, M., Strauss, M., et al. (2017). The Eukaryotic CO2-Concentrating Organelle Is Liquid-like and Exhibits Dynamic Reorganization. Cell, 171(1), 148-162.e19. doi:10.1016/j.cell.2017.08.008.

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Freeman Rosenzweig, Elizabeth S.1, Autor
Xu, Bin1, Autor
Kuhn Cuellar, Luis2, Autor           
Martinez-Sanchez, Antonio2, Autor           
Schaffer, Miroslava2, Autor           
Strauss, Mike3, Autor           
Cartwright, Heather N.1, Autor
Ronceray, Pierre1, Autor
Plitzko, Jürgen M.2, Autor           
Förster, Friedrich2, Autor           
Wingreen, Ned S.1, Autor
Engel, Benjamin D.2, Autor           
Mackinder, Luke C. M.1, Autor
Jonikas, Martin C.1, Autor
Affiliations:
1external, ou_persistent22              
2Baumeister, Wolfgang / Molecular Structural Biology, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565142              
3Scientific Service Groups, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565170              

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Schlagwörter: CHLAMYDOMONAS-REINHARDTII; RUBISCO ACTIVASE; DISORDERED PROTEINS; PYRENOID FORMATION; GREEN-ALGAE; CARBOXYSOMES; TOMOGRAPHY; CO2; CARBOXYLASE/OXYGENASE; PHOSPHORYLATIONBiochemistry & Molecular Biology; Cell Biology;
 Zusammenfassung: Approximately 30%-40% of global CO2 fixation occurs inside a non-membrane-bound organelle called the pyrenoid, which is found within the chloroplasts of most eukaryotic algae. The pyrenoid matrix is densely packed with the CO2-fixing enzyme Rubisco and is thought to be a crystalline or amorphous solid. Here, we show that the pyrenoid matrix of the unicellular alga Chlamydomonas reinhardtii is not crystalline but behaves as a liquid that dissolves and condenses during cell division. Furthermore, we show that new pyrenoids are formed both by fission and de novo assembly. Our modeling predicts the existence of a "magic number'' effect associated with special, highly stable heterocomplexes that influences phase separation in liquid-like organelles. This view of the pyrenoid matrix as a phase-separated compartment provides a paradigm for understanding its structure, biogenesis, and regulation. More broadly, our findings expand our understanding of the principles that govern the architecture and inheritance of liquid-like organelles.

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Sprache(n): eng - English
 Datum: 2017-09-212017
 Publikationsstatus: Erschienen
 Seiten: 34
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: ISI: 000411331800017
DOI: 10.1016/j.cell.2017.08.008
 Art des Abschluß: -

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Titel: Cell
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Cambridge, Mass. : Cell Press
Seiten: - Band / Heft: 171 (1) Artikelnummer: - Start- / Endseite: 148 - 162.e19 Identifikator: ISSN: 0092-8674
CoNE: https://pure.mpg.de/cone/journals/resource/954925463183