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  From Chaperonins to Rubisco Assembly and Metabolic Repair.

Hayer-Hartl, M. (2017). From Chaperonins to Rubisco Assembly and Metabolic Repair. Protein science, 26(12), 2324-2333. doi:10.1002/pro.3309.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-549A-A Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-549B-8
Genre: Journal Article

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 Creators:
Hayer-Hartl, Manajit1, Author              
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1Hayer-Hartl, Manajit / Chaperonin-assisted Protein Folding, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565153              

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Free keywords: Dorothy Crowfoot Hodgkin; Rubisco; Rubisco activase; assembly; chaperonin; metabolic repair; molecular chaperones; phosphatase; protein folding
 Abstract: Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) mediates the fixation of atmospheric CO2 in photosynthesis by catalyzing the carboxylation of the 5-carbon sugar ribulose-1,5-bisphosphate (RuBP). Despite its pivotal role, Rubisco is an inefficient enzyme and thus has been a key target for bioengineering. However, efforts to increase crop yields by Rubisco engineering remain unsuccessful, due in part to the complex machinery of molecular chaperones required for Rubisco biogenesis and metabolic repair. While the large subunit of Rubisco generally requires the chaperonin system for folding, the evolution of the hexadecameric Rubisco from its dimeric precursor resulted in the dependence on an array of additional factors required for assembly. Moreover, Rubisco function can be inhibited by a range of sugar-phosphate ligands. Metabolic repair of Rubisco depends on remodeling by the ATP-dependent Rubisco activase and hydrolysis of inhibitors by specific phosphatases. This review highlights our work towards understanding the structure and mechanism of these auxiliary machineries. This article is protected by copyright. All rights reserved. © 2017 The Protein Society.

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Language(s): eng - English
 Dates: 2017-11-222017
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: ISI: 28960553
DOI: 10.1002/pro.3309
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Project name : -
Grant ID : SFB1035
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft

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Title: Protein science
Source Genre: Journal
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Publ. Info: The Protein Society
Pages: - Volume / Issue: 26 (12) Sequence Number: - Start / End Page: 2324 - 2333 Identifier: ISSN: 1469-896X