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  Pattern formation by curvature-inducing proteins on spherical membranes

Agudo-Canalejo, J., & Golestanian, R. (2017). Pattern formation by curvature-inducing proteins on spherical membranes. New Journal of Physics, 19: 125013. doi:10.1088/1367-2630/aa983c.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-1751-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0000-354B-1
Genre: Journal Article

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 Creators:
Agudo-Canalejo, Jaime1, Author              
Golestanian, Ramin, Author
Affiliations:
1Reinhard Lipowsky, Theorie & Bio-Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863327              

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Free keywords: Physics, Biological Physics, physics.bio-ph, Condensed Matter, Soft Condensed Matter, cond-mat.soft, Open Access
 Abstract: Spatial organisation is a hallmark of all living cells, and recreating it in model systems is a necessary step in the creation of synthetic cells. It is therefore of both fundamental and practical interest to better understand the basic mechanisms underlying spatial organisation in cells. In this work, we use a continuum model of membrane and protein dynamics to study the behaviour of curvature-inducing proteins on membranes of spherical shape, such as living cells or lipid vesicles. We show that the interplay between curvature energy, entropic forces, and the geometric constraints on the membrane can result in the formation of patterns of highly-curved/protein-rich and weakly-curved/protein-poor domains on the membrane. The spontaneous formation of such patterns can be triggered either by an increase in the average density of curvature-inducing proteins, or by a relaxation of the geometric constraints on the membrane imposed by a turgor pressure or the tethering of the membrane to a cell wall or cortex. These two parameters can also be tuned to select the size and number of the protein-rich domains that arise upon pattern formation. The very general mechanism presented here could be related to protein self-organisation in many biological systems.

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 Dates: 2017-05-232017-12
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: arXiv: 1705.08425
URI: http://arxiv.org/abs/1705.08425
DOI: 10.1088/1367-2630/aa983c
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Title: New Journal of Physics
  Abbreviation : New J. Phys.
Source Genre: Journal
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Publ. Info: Bristol : IOP Publishing
Pages: - Volume / Issue: 19 Sequence Number: 125013 Start / End Page: - Identifier: ISSN: 1367-2630