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  Evaluating the maintenance of disease-associated variation at the blood group-related gene B4galnt2 in house mice

Vallier, M., Abou Chakra, M., Hindersin, L., Linnenbrink, M., Traulsen, A., & Baines, J. F. (2017). Evaluating the maintenance of disease-associated variation at the blood group-related gene B4galnt2 in house mice. BMC Evolutionary Biology, 17(187), 1-22. doi:10.1186/s12862-017-1035-7.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-0F5F-A Version Permalink: http://hdl.handle.net/21.11116/0000-0001-AC06-7
Genre: Journal Article

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 Creators:
Vallier, Marie1, Author              
Abou Chakra, Maria2, Author              
Hindersin, Laura2, Author              
Linnenbrink, Miriam3, Author              
Traulsen, Arne2, Author              
Baines, John F.1, Author              
Affiliations:
1Guest Group Evolutionary Genomics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445638              
2Department Evolutionary Theory, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445641              
3Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445635              

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Free keywords: B4galnt2; Blood group; Host-pathogen interaction; Balancing selection; Trade-off; Evolutionary game theory; Wright-fisher process
 Abstract: B4galnt2 is a blood group-related glycosyltransferase that displays cis-regulatory variation for its tissue-specific expression patterns in house mice. The wild type allele, found e.g. in the C57BL/6 J strain, directs intestinal expression of B4galnt2, which is the pattern observed among vertebrates, including humans. An alternative allele class found in the RIIIS/J strain and other mice instead drives expression in blood vessels, which leads to a phenotype similar to type 1 von Willebrand disease (VWD), a common human bleeding disorder. We previously showed that alternative B4galnt2 alleles are subject to long-term balancing selection in mice and that variation in B4galnt2 expression influences host-microbe interactions in the intestine. This suggests that the costs of prolonged bleeding in RIIIS/J allele-bearing mice might be outweighed by benefits associated with resistance against gastrointestinal pathogens. However, the conditions under which such trade-offs could lead to the long-term maintenance of disease-associated variation at B4galnt2 are unclear.

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Language(s): eng - English
 Dates: 2017-03-272017-08-042017-08-14
 Publication Status: Published online
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 Identifiers: DOI: 10.1186/s12862-017-1035-7
BibTex Citekey: Vallier2017
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Title: BMC Evolutionary Biology
Source Genre: Journal
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Publ. Info: BioMed Central
Pages: 22 Volume / Issue: 17 (187) Sequence Number: - Start / End Page: 1 - 22 Identifier: ISSN: 1471-2148
CoNE: /journals/resource/111000136905006