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  Inflexible functional connectivity of the dorsal anterior cingulate cortex in adolescent major depressive disorder

Ho, T. C., Sacchet, M. D., Connolly, C. G., Margulies, D. S., Tymofiyeva, O., Paulus, M. P., et al. (2017). Inflexible functional connectivity of the dorsal anterior cingulate cortex in adolescent major depressive disorder. Neuropsychopharmacology, 42(12), 2434-2445. doi:10.1038/npp.2017.103.

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Genre: Zeitschriftenartikel

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externe Referenz:
https://doi.org/10.1038/npp.2017.103 (Verlagsversion)
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OA-Status:
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 Urheber:
Ho, Tiffany C.1, 2, Autor
Sacchet, Matthew D.2, 3, Autor
Connolly, Colm G.1, Autor
Margulies, Daniel S.4, Autor           
Tymofiyeva, Olga5, Autor
Paulus, Martin P.6, 7, Autor
Simmons, Alan N.7, 8, Autor
Gotlib, Ian H.2, 9, Autor
Yang, Tony T.1, Autor
Affiliations:
1Division of Child and Adolescent Psychiatry, Department of Psychiatry, University of California, San Francisco, CA, USA, ou_persistent22              
2Department of Psychology, Stanford University, CA, USA, ou_persistent22              
3Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA, USA, ou_persistent22              
4Max Planck Research Group Neuroanatomy and Connectivity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_1356546              
5Department of Radiology, University of California, San Francisco, CA, USA, ou_persistent22              
6Laureate Institute for Brain Research, Tulsa, OK, USA, ou_persistent22              
7Department of Psychiatry, University of California, San Francisco, CA, USA, ou_persistent22              
8Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, University of California San Diego, CA, USA, ou_persistent22              
9Neurosciences Program, Stanford University, CA, USA, ou_persistent22              

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Schlagwörter: Adolescent; Adolescent Behavior; Depressive Disorder, Major; Female; Gyrus Cinguli; Humans; Magnetic Resonance Imaging; Male; Nerve Net; Reaction Time
 Zusammenfassung: Recent evidence suggests that anterior cingulate cortex (ACC) maturation during adolescence contributes to or underlies the development of major depressive disorder (MDD) during this sensitive period. The ACC is a structure that sits at the intersection of several task-positive networks (eg, central executive network, CEN), which are still developing during adolescence. While recent work using seed-based approaches indicate that depressed adolescents show limited task-evoked vs resting-state connectivity (termed ‘inflexibility’) between the ACC and task-negative networks, no study has used network-based approaches to investigate inflexibility of the ACC in task-positive networks to understand adolescent MDD. Here, we used graph theory to compare flexibility of network-level topology in eight subregions of the ACC (spanning three task-positive networks) in 42 unmedicated adolescents with MDD and 53 well-matched healthy controls. All participants underwent fMRI scanning during resting state and a response inhibition task that robustly engages task-positive networks. Relative to controls, depressed adolescents were characterized by inflexibility in local efficiency of a key ACC node in the CEN: right dorsal anterior cingulate cortex/medial frontal gyrus (R dACC/MFG). Furthermore, individual differences in flexibility of local efficiency of R dACC/MFG significantly predicted inhibition performance, consistent with current literature demonstrating that flexible network organization affords successful cognitive control. Finally, reduced local efficiency of dACC/MFG during the task was significantly associated with an earlier age of depression onset, consistent with prior work suggesting that MDD may alter functional network development. Our results support a neurodevelopmental hypothesis of MDD wherein dysfunctional self-regulation is potentially reflected by altered ACC maturation.

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Sprache(n): eng - English
 Datum: 2017-04-152016-11-292017-05-142017-07-192017-11
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1038/npp.2017.103
PMID: 28553837
PMC: PMC5645733
Anderer: Epub 2017
 Art des Abschluß: -

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Projektname : -
Grant ID : PDF-1-064-13
Förderprogramm : -
Förderorganisation : American Foundation for Suicide Prevention
Projektname : -
Grant ID : 080700
Förderprogramm : IGERT Award
Förderorganisation : National Science Foundation (NSF)
Projektname : -
Grant ID : DGE-1147470
Förderprogramm : Graduate Research Fellowship Award
Förderorganisation : National Science Foundation (NSF)
Projektname : -
Grant ID : R01MH085734 ; R01MH101495 ; R01HD072074 ; R21AT009173
Förderprogramm : -
Förderorganisation : National Institutes of Health (NIH)
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : UCSF Research Evaluation and Allocation Committee
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : Jacobs Foundation
Projektname : -
Grant ID : I-1-CX000715
Förderprogramm : -
Förderorganisation : Center of Excellence in Stress and Mental Health and Veteran’s Affairs
Projektname : -
Grant ID : -
Förderprogramm : Young Investigator Award
Förderorganisation : Brain and Behavior Research Foundation (BBRF)

Quelle 1

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Titel: Neuropsychopharmacology
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: New York, NY : No longer published by Elsevier
Seiten: - Band / Heft: 42 (12) Artikelnummer: - Start- / Endseite: 2434 - 2445 Identifikator: ISSN: 0893-133X
CoNE: https://pure.mpg.de/cone/journals/resource/954925558485