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  Electromechanical optical mapping

Christoph, J., Schröder-Schetelig, J., & Luther, S. (2017). Electromechanical optical mapping. Progress in Biophysics and Molecular Biology, 130, 150-169. doi:10.1016/j.pbiomolbio.2017.09.015.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-1312-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-30B5-C
Genre: Journal Article

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 Creators:
Christoph, Jan1, Author              
Schröder-Schetelig, Johannes1, Author              
Luther, Stefan1, Author              
Affiliations:
1Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society, ou_2063288              

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Free keywords: Optical mapping; Cardiac fibrillation; Excitation-contraction coupling; Image registration; Motion artifact; Motion tracking
 Abstract: Optical mapping is a widely used imaging technique for investigating cardiac electrophysiology in intact, Langendorff-perfused hearts. Mechanical contraction of cardiac tissue, however, may result in severe motion artifacts and significant distortion of the fluorescence signals. Therefore, pharmacological uncoupling is widely used to reduce tissue motion. Recently, various image processing algorithms have been proposed to reduce motion artifacts. We will review these technological developments. Furthermore, we will present a novel approach for the three-dimensional, marker-free reconstruction of contracting Langendorff-perfused intact hearts under physiological conditions. The algorithm allows disentangling the fluorescence signals (e.g. membrane voltage or intracellular calcium) from the mechanical motion (e.g. tissue strain). We will discuss the algorithms reconstruction accuracy, resolution, and robustness using experimental data from Langendorff-perfused rabbit hearts.

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Language(s): eng - English
 Dates: 2017-09-222017-11
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.pbiomolbio.2017.09.015
 Degree: -

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Title: Progress in Biophysics and Molecular Biology
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 130 Sequence Number: - Start / End Page: 150 - 169 Identifier: -