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  Gut microbiota in Parkinson disease in a northern German cohort

Hopfner, F., Künstner, A., Müller, S., Künzel, S., Zeuner, K., Margraf, N., et al. (2017). Gut microbiota in Parkinson disease in a northern German cohort. Brain Research, 1667, 41-45. doi:10.1016/j.brainres.2017.04.019.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-1A8A-F Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-1A8B-D
Genre: Journal Article

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 Creators:
Hopfner, F., Author
Künstner, A.1, Author              
Müller, S.H., Author
Künzel, S.2, Author              
Zeuner, K.E., Author
Margraf, N.G., Author
Deuschl, G., Author
Baines, J. F.1, Author              
Kuhlenbäumer, G., Author
Affiliations:
1Guest Group Evolutionary Genomics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445638              
2Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445635              

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Free keywords: Gut microbiota; Parkinson disease; Stool
 Abstract: Pathologic and epidemiologic studies suggest that Parkinson disease (PD) may in some cases start in the enteric nervous system and spread via the vagal nerve to the brainstem. Mounting evidence suggests that the gut microbiome plays an important role in the communication between gut and brain and that alteration of the gut microbiome is involved in the pathogenesis of numerous diseases, including Parkinson disease. The aim of this study was to determine whether Parkinson disease is associated with qualitative or quantitative changes in the gut microbiome. We analyzed the gut microbiome in 29 PD cases and 29 age-matched controls by next-generation-sequencing of the 16S rRNA gene and compared diversity indices and bacterial abundances between cases and controls. Alpha diversity measures and the abundance of major phyla did not differ between cases and controls. Beta diversity analyses and analysis on the bacterial family level revealed significant differences between cases and controls for four bacterial families. In keeping with recently published studies, Lactobacillaceae were more abundant in cases. Barnesiellaceae and Enterococcacea were also more abundant in cases in this study but not in other studies. Larger studies, accounting for drug effects and further functional investigations of the gut microbiome are necessary to delineate the role of the gut microbiome in the pathogenesis of PD. © 2017 Elsevier B.V.

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Language(s): eng - English
 Dates: 2017-04-292017-01-052017-04-292017-05-122017
 Publication Status: Published in print
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Title: Brain Research
  Other : Brain Res.
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 1667 Sequence Number: - Start / End Page: 41 - 45 Identifier: ISSN: 0006-8993
CoNE: https://pure.mpg.de/cone/journals/resource/954926250616