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  Odd skipped-related 1 identifies a population of embryonic fibro-adipogenic progenitors regulating myogenesis during limb development

Vallecillo-García, P., Orgeur, M., vom Hofe-Schneider, S., Stumm, J., Kappert, V., Ibrahim, D., et al. (2017). Odd skipped-related 1 identifies a population of embryonic fibro-adipogenic progenitors regulating myogenesis during limb development. Nature Communications, 8(1): 1218. doi:10.1038/s41467-017-01120-3.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-1F26-7 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-1F27-5
Genre: Journal Article

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Vallecillo-García, Pedro, Author
Orgeur, Mickael , Author
vom Hofe-Schneider, Sophie , Author
Stumm, Jürgen, Author
Kappert, Verena, Author
Ibrahim, Daniel1, Author              
Börno, Stefan T.2, Author              
Hayashi, Shinichiro , Author
Relaix, Frédéric , Author
Hildebrandt, Katrin , Author
Sengle, Gerhard , Author
Koch, Manuel, Author
Timmermann, Bernd2, Author              
Marazzi, Giovanna , Author
Sassoon, David A. , Author
Duprez, Delphine , Author
Stricker, Sigmar1, Author              
Affiliations:
1Research Group Development & Disease (Head: Stefan Mundlos), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433557              
2Sequencing (Head: Bernd Timmermann), Scientific Service (Head: Christoph Krukenkamp), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479670              

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 Abstract: Fibro-adipogenic progenitors (FAPs) are an interstitial cell population in adult skeletal muscle that support muscle regeneration. During development, interstitial muscle connective tissue (MCT) cells support proper muscle patterning, however the underlying molecular mechanisms are not well understood and it remains unclear whether adult FAPs and embryonic MCT cells share a common lineage. We show here that mouse embryonic limb MCT cells expressing the transcription factor Osr1, differentiate into fibrogenic and adipogenic cells in vivo and in vitro defining an embryonic FAP-like population. Genetic lineage tracing shows that developmental Osr1+ cells give rise to a subset of adult FAPs. Loss of Osr1 function leads to a reduction of myogenic progenitor proliferation and survival resulting in limb muscle patterning defects. Transcriptome and functional analyses reveal that Osr1+ cells provide a critical pro-myogenic niche via the production of MCT specific extracellular matrix components and secreted signaling factors.

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Language(s): eng - English
 Dates: 2017-08-172017-10-31
 Publication Status: Published online
 Pages: -
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 Rev. Method: -
 Identifiers: DOI: 10.1038/s41467-017-01120-3
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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 8 (1) Sequence Number: 1218 Start / End Page: - Identifier: ISSN: 2041-1723
CoNE: /journals/resource/2041-1723