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  Hyperpolarization of amino acid derivatives in water for biological applications.

Glöggler, S., Wagner, S., & Bouchard, L. S. (2015). Hyperpolarization of amino acid derivatives in water for biological applications. The Royal Society of Chemistry, 6, 4261-4266. doi:10.1039/C5SC00503E.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002E-2398-A Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002E-239B-4
Genre: Journal Article

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2495902.pdf (Publisher version), 443KB
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 Creators:
Glöggler, S.1, Author           
Wagner, S., Author
Bouchard, L. S., Author
Affiliations:
1Research Group of NMR Signal Enhancement, MPI for Biophysical Chemistry, Max Planck Society, ou_2396691              

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 Abstract: We report on the successful synthesis and hyperpolarization of N-unprotected α-amino acid ethyl propionate esters and extensively, on an alanine derivative hyperpolarized by PHIP (4.4 ± 1.0% 13C-polarization), meeting required levels for in vivo detection. Using water as solvent increases biocompatibility and the absence of N-protection is expected to maintain biological activity.

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Language(s): eng - English
 Dates: 2015-05-262015
 Publication Status: Issued
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1039/C5SC00503E
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Title: The Royal Society of Chemistry
Source Genre: Journal
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Pages: - Volume / Issue: 6 Sequence Number: - Start / End Page: 4261 - 4266 Identifier: -