English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Spermidine Suppresses Age-Associated Memory Impairment by Preventing Adverse Increase of Presynaptic Active Zone Size and Release

Gupta, V. K., Pech, U., Bhukel, A., Fulterer, A., Ender, A., Mauermann, S. F., et al. (2016). Spermidine Suppresses Age-Associated Memory Impairment by Preventing Adverse Increase of Presynaptic Active Zone Size and Release. PLOS BIOLOGY, 14(9): e1002563. doi:10.1371/journal.pbio.1002563.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-23FB-C Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-23FC-A
Genre: Journal Article

Files

show Files
hide Files
:
Gupta.PDF (Publisher version), 5MB
Name:
Gupta.PDF
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
© 2016 Gupta et al

Locators

show

Creators

show
hide
 Creators:
Gupta, Varun K., Author
Pech, Ulrike, Author
Bhukel, Anuradha, Author
Fulterer, Andreas, Author
Ender, Anatoli, Author
Mauermann, Stephan F., Author
Andlauer, Till F. M., Author
Antwi-Adjei, Emmanuel, Author
Beuschel, Christine, Author
Thriene, Kerstin, Author
Maglione, Marta, Author
Quentin, Christine, Author
Bushow, Rene, Author
Schwaerzel, Martin, Author
Mielke, Thorsten1, Author              
Dengjel, Joern, Author
Fiala, Andre, Author
Sigrist, Stephan J., Author
Affiliations:
1Microscopy and Cryo-Electron Microscopy (Head: Thorsten Mielke), Scientific Service (Head: Christoph Krukenkamp), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479668              

Content

show
hide
Free keywords: -
 Abstract: Memories are assumed to be formed by sets of synapses changing their structural or functional performance. The efficacy of forming new memories declines with advancing age, but the synaptic changes underlying age-induced memory impairment remain poorly understood. Recently, we found spermidine feeding to specifically suppress age-dependent impairments in forming olfactory memories, providing a mean to search for synaptic changes involved in age-dependent memory impairment. Here, we show that a specific synaptic compartment, the presynaptic active zone (AZ), increases the size of its ultrastructural elaboration and releases significantly more synaptic vesicles with advancing age. These age-induced AZ changes, however, were fully suppressed by spermidine feeding. A genetically enforced enlargement of AZ scaffolds (four gene-copies of BRP) impaired memory formation in young animals. Thus, in the Drosophila nervous system, aging AZs seem to steer towards the upper limit of their operational range, limiting synaptic plasticity and contributing to impairment of memory formation. Spermidine feeding suppresses age-dependent memory impairment by counteracting these age-dependent changes directly at the synapse.

Details

show
hide
Language(s): eng - English
 Dates: 2016-08-262016-09-29
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: PLOS BIOLOGY
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 14 (9) Sequence Number: e1002563 Start / End Page: - Identifier: ISSN: 1545-7885