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  Adaptive evolution by spontaneous domain fusion and protein relocalization

Farr, A. D., Remigi, P., & Rainey, P. B. (2017). Adaptive evolution by spontaneous domain fusion and protein relocalization. Nature Ecology & Evolution, 1, 1562-1568. doi:10.1038/s41559-017-0283-7.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-263C-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-CEBB-2
Genre: Journal Article

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 Creators:
Farr, Andrew D.1, Author              
Remigi, Philippe2, Author
Rainey, Paul B.2, Author              
Affiliations:
1External Organizations, ou_persistent22              
2Department Microbial Population Biology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_2421699              

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Free keywords: evolutionary genetics; microbial genetics
 Abstract: Knowledge of adaptive processes encompasses understanding the emergence of new genes. Computational analyses of genomes suggest that new genes can arise by domain swapping; however, empirical evidence has been lacking. Here we describe a set of nine independent deletion mutations that arose during selection experiments with the bacterium Pseudomonas fluorescens in which the membrane-spanning domain of a fatty acid desaturase became translationally fused to a cytosolic di-guanylate cyclase, generating an adaptive 'wrinkly spreader' phenotype. Detailed genetic analysis of one gene fusion shows that the mutant phenotype is caused by relocalization of the di-guanylate cyclase domain to the cell membrane. The relative ease by which this new gene arose, along with its functional and regulatory effects, provides a glimpse of mutational events and their consequences that are likely to have a role in the evolution of new genes. © 2017 The Author(s).

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Language(s): eng - English
 Dates: 2016-12-142017-07-182017-08-282017
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1038/s41559-017-0283-7
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Title: Nature Ecology & Evolution
  Other : Nature Ecology and Evolution
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 1 Sequence Number: - Start / End Page: 1562 - 1568 Identifier: ISSN: 2397-334X
CoNE: https://pure.mpg.de/cone/journals/resource/2397-334X