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  Elastic modulus dependence on the specific adhesion of hydrogels

Wang, H., Jacobi, F., Waschke, J., Hartmann, L., Löwen, H., & Schmidt, S. (2017). Elastic modulus dependence on the specific adhesion of hydrogels. Advanced Functional Materials, 27(41): 1702040. doi:10.1002/adfm.201702040.

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 Creators:
Wang, Hanqing1, Author
Jacobi, Fawad1, Author
Waschke, Johannes2, Author           
Hartmann, Laura1, Author
Löwen, Hartmut3, Author
Schmidt, Stephan1, Author
Affiliations:
1Institute for Organic and Macromolecular Chemistry, Heinrich Heine University Düsseldorf, Germany, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
3Institute for Theoretical Physics II: Soft Matter, Heinrich Heine University Düsseldorf, Germany, ou_persistent22              

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Free keywords: Biointerfaces; Biomimetic hydrogels; Cell adhesion; Glycocalyx; Soft colloidal probes
 Abstract: Mechanosensitivity in biology, e.g., cells responding to material stiffness, is important for the design of synthetic biomaterials. It is caused by protein receptors able to undergo conformational changes depending on mechanical stress during adhesion processes. Here the elastic modulus dependence of adhesive interactions is systematically quantified using ligand–receptor model systems that are generally not thought to be mechanosensitive: biotin–avidin, mannose–concanavalin A, and electrostatic interactions between carboxylic acids and polycationic surfaces. Interactions are measured by microgel sensors of different stiffness adhering to surfaces presenting a corresponding binding partner. Adhesion is generally decreased for softer microgels due to reduced density of binding partners. Density-normalized data show that low-affinity carbohydrate ligands exhibit reduced binding in softer networks, probably due to increased network conformational entropy. However, in case of stronger interactions with large interaction range (electrostatic) and large lifetime (biotin–avidin) density normalized adhesion is increased. This suggests compensation of entropic repulsion for softer networks probably due to their increased mechanical deformation upon microgel adhesion and enhanced cooperative binding. In essence, experiments indicate that soft interacting polymer materials exhibit entropic repulsion, which can be overcome by strongly interacting species in the network harnessing network flexibility in order to increase adhesion.

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Language(s): eng - English
 Dates: 2017-07-062017-04-182017-09-042017-11-03
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/adfm.201702040
 Degree: -

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Project name : -
Grant ID : SCHM 2748/3‐1 ; LO 418/16
Funding program : -
Funding organization : German Research Foundation (DFG)

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Title: Advanced Functional Materials
  Other : Adv. Funct. Mater.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH Verlag GmbH
Pages: - Volume / Issue: 27 (41) Sequence Number: 1702040 Start / End Page: - Identifier: ISSN: 1616-301X
CoNE: https://pure.mpg.de/cone/journals/resource/954925596563