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  Crystal structure of a bicupin protein HutD involved in histidine utilization in Pseudomonas

Gerth, M., Liu, Y., Jiao, W., Zhang, X.-X., Baker, E., Lott, J., et al. (2017). Crystal structure of a bicupin protein HutD involved in histidine utilization in Pseudomonas. Proteins: Structure, Function, and Bioinformatics, 85(8), 1580-1588. doi:10.1002/prot.25303.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-2C6A-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-2C6C-2
Genre: Journal Article

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 Creators:
Gerth, M.L., Author
Liu, Y.1, Author              
Jiao, W., Author
Zhang, X.-X., Author
Baker, E.N., Author
Lott, J.S., Author
Rainey, P. B.2, Author              
Johnston, J.M., Author
Affiliations:
1Dept. of Plant Breeding and Genetics (Maarten Koornneef), MPI for Plant Breeding Research, Max Planck Society, ou_1113569              
2Department Microbial Population Biology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_2421699              

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Free keywords: cupin; crystal structure; ligand binding
 Abstract: Cupins form one of the most functionally diverse superfamilies of proteins, with members performing a wide range of catalytic, non-catalytic, and regulatory functions. HutD is a predicted bicupin protein that is involved in histidine utilization (Hut) in Pseudomonas species. Previous genetic analyses have suggested that it limits the upper level of Hut pathway expression, but its mechanism of action is unknown. Here, we have determined the structure of PfluHutD at 1.74 Å resolution in several crystallization conditions, and identified N-formyl-l-glutamate (FG, a Hut pathway intermediate) as a potential ligand in vivo. Proteins 2017; 85:1580–1588. © 2017 Wiley Periodicals, Inc.

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Language(s): eng - English
 Dates: 2017-03-292016-12-152017-04-042017-04-062017-04-25
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1002/prot.25303
BibTex Citekey: Gerth20171580
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Title: Proteins: Structure, Function, and Bioinformatics
Source Genre: Journal
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Publ. Info: New York, NY : John Wiley & Sons
Pages: - Volume / Issue: 85 (8) Sequence Number: - Start / End Page: 1580 - 1588 Identifier: ISSN: 0887-3585
CoNE: /journals/resource/954925553393_1