De novo synaptogenesis induced by GABA in the developing mouse cortex

Oh, Won Chan; Lutzu, Stefano; Castillo, Pablo E.; Kwon, Hyung-Bae

doi:10.1126/science.aaf5206

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De novo synaptogenesis induced by GABA in the developing mouse cortex

Oh, W. C., Lutzu, S., Castillo, P. E., & Kwon, H.-B. (2016). De novo synaptogenesis induced by GABA in the developing mouse cortex. Science (New York, N.Y.), 353(6303), 1037-1040. doi:10.1126/science.aaf5206.

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Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-002E-2C85-8 Versions-Permalink: https://hdl.handle.net/11858/00-001M-0000-002E-2C94-6

Genre: Zeitschriftenartikel

Alternativer Titel : Science (New York, N.Y.)

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Oh, Won Chan¹, Autor
Lutzu, Stefano², Autor
Castillo, Pablo E.², Autor
Kwon, Hyung-Bae^{1, 3}, Autor

Affiliations:
1Max Planck Florida Institute for Neuroscience, Max Planck Society, One Max Planck Way, Jupiter FL 33458, USA, ou_1950288
2External Organizations, ou_persistent22
3MPI of Neurobiology, Max Planck Society, Am Klopferspitz 18, 82152 Martinsried, DE, ou_1110547

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Zusammenfassung: Dendrites of cortical pyramidal neurons contain intermingled excitatory and inhibitory synapses. Here we study the local mechanisms that regulate the formation and distribution of synapses. We show that local γ-aminobutyric acid (GABA) release on dendrites of mouse cortical layer 2/3 pyramidal neurons can induce gephyrin puncta and dendritic spine formation via GABAA receptor activation and voltage-gated calcium channels during early postnatal development. Furthermore, the newly formed inhibitory and excitatory synaptic structures rapidly gain functions. Bidirectional manipulation of GABA release from somatostatin-positive interneurons increased and decreased the number of gephyrin puncta and dendritic spines, respectively. These results highlight a non-canonical function of GABA as a local synaptogenic element shaping the early establishment of neuronal circuitry in mouse cortex.