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  Host modification of a bacterial quorum-sensing signal induces a phenotypic switch in bacterial symbionts

Pietschke, C., Treitz, C., Forêt, S., Schultze, A., Künzel, S., Tholey, A., et al. (2017). Host modification of a bacterial quorum-sensing signal induces a phenotypic switch in bacterial symbionts. Proceedings of the National Academy of Sciences of the United States of America, 114(40), E8488-E8497. doi:10.1073/pnas.1706879114.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-2DB7-1 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-2DB8-0
Genre: Journal Article

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http://www.pnas.org/content/114/40/E8488 (Publisher version)
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 Creators:
Pietschke, Cleo, Author
Treitz, Christian, Author
Forêt, Sylvain, Author
Schultze, Annika, Author
Künzel, Sven1, Author              
Tholey, Andreas, Author
Bosch, Thomas C. G. , Author
Fraune, Sebastian, Author
Affiliations:
1Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445635              

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Free keywords: Host–microbe interaction; Hydra; Interference; Quorum quenching; Quorum sensing
 Abstract: Bacterial communities colonize epithelial surfaces of most animals. Several factors, including the innate immune system, mucus composition, and diet, have been identified as determinants of host-associated bacterial communities. Here we show that the early branching metazoan Hydra is able to modify bacterial quorum-sensing signals. We identified a eukaryotic mechanism that enables Hydra to specifically modify long-chain 3-oxo-homoserine lactones into their 3-hydroxy-HSL counterparts. Expression data revealed that Hydra’s main bacterial colonizer, Curvibacter sp., responds differentially to N-(3-hydroxy-dodecanoyl)-L-homoserine lactone (3OHC12-HSL) and N-(3-oxodode-canoyl)-L-homoserine lactone (3OC12-HSL). Investigating the impacts of the different N-acyl-HSLs on host colonization elucidated that 3OHC12-HSL allows and 3OC12-HSL represses host colonization of Curvibacter sp. These results show that an animal manipulates bacterial quorum-sensing signals and that this modification leads to a phenotypic switch in the bacterial colonizers. This mechanism may enable the host to manipulate the gene expression and thereby the behavior of its bacterial colonizers. © 2017, National Academy of Sciences. All rights reserved.

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Language(s): eng - English
 Dates: 2017-05-032017-08-092017-09-182017-10-03
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
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Title: Proceedings of the National Academy of Sciences of the United States of America
  Other : Proceedings of the National Academy of Sciences of the USA
  Other : Proc. Acad. Sci. USA
  Other : Proc. Acad. Sci. U.S.A.
  Abbreviation : PNAS
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Washington, D.C. : National Academy of Sciences
Pages: - Volume / Issue: 114 (40) Sequence Number: - Start / End Page: E8488 - E8497 Identifier: ISSN: 0027-8424
CoNE: /journals/resource/954925427230