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  Gastric-bypass surgery induced widespread neural plasticity of the obese human brain

Rullmann, M., Preusser, S., Poppitz, S., Heba, S., Hoyer, J., Schütz, T., et al. (2018). Gastric-bypass surgery induced widespread neural plasticity of the obese human brain. NeuroImage, 172, 853-863. doi:10.1016/j.neuroimage.2017.10.062.

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 Urheber:
Rullmann, Michael1, 2, 3, 4, Autor           
Preusser, Sven3, Autor           
Poppitz, Sindy1, 3, Autor
Heba, Stefanie1, 5, 6, Autor
Hoyer, Jana7, Autor
Schütz, Tatjana1, 8, Autor
Dietrich, Arne1, 8, Autor
Mueller, Karsten9, Autor           
Pleger, Burkhard1, 3, 4, 5, 6, Autor           
Affiliations:
1Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
2Department of Nuclear Medicine, University of Leipzig, Germany, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
4Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany, ou_persistent22              
5Department of Neurology, University Hospital Bergmannsheil, Bochum, Germany, ou_persistent22              
6Integration and Representation of Sensory Processes, Ruhr University, Bochum, Germany, ou_persistent22              
7Department of Psychology, TU Dresden, Germany, ou_persistent22              
8Department of Bariatric Surgery, University Hospital Leipzig, Germany, ou_persistent22              
9Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              

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Schlagwörter: Magnetic resonance imaging; Gray matter density; White matter density; White matter diffusion; Amplitudes of low frequency fluctuations; ALFF; Regional homogeneity; ReHo; Brain plasticity; Body weight; Bariatric surgery; Gastric-bypass surgery
 Zusammenfassung: Bariatric surgery has become the gold standard for the treatment of morbid obesity (body mass index (BMI) ≥ 40 kg/m2), but only few studies investigated its plastic influences on the obese brain. In this longitudinal study, we combined structural and functional magnetic resonance brain imaging (MRI) in 27 patients (BMI 47.8 ± 5.5 kg/m2) undergoing gastric-bypass surgery and 14 non-obese matched controls (BMI 24.7 ± 3.4 kg/m2). Over the first year after surgery, patients presented widespread changes in white matter density (WMD) as well as gray matter density (GMD) in the cerebral cortex of all lobes, subcortical structures, the brainstem as well as the cerebellum, but no changes in white matter water diffusivity throughout the brain. Voxel-by-voxel regression analyses revealed that all GMD and WMD changes were well associated with elevated regional homogeneity of spontaneous neural activity (ReHo) in blood-oxygenation level-dependent signals. Spatial-temporal integration of structural and functional MRI suggests that gastric-bypass surgery induces widespread plastic changes in brain structure that concurrently homogenizes the functional profile of the cortex, subcortical regions as well as white matter structures.

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Sprache(n): eng - English
 Datum: 2017-06-222017-10-272017-10-282018-05-15
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1016/j.neuroimage.2017.10.062
PMID: 29107772
Anderer: Epub 2017
 Art des Abschluß: -

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Projektname : -
Grant ID : 01E01001
Förderprogramm : -
Förderorganisation : IFB Adiposity Diseases, German Federal Ministry of Education and Research (BMBF)
Projektname : Obesity Mechanisms / SFB 1052
Grant ID : -
Förderprogramm : -
Förderorganisation : German Research Foundation (DFG)
Projektname : Integration and Representation of Sensory Processes / SFB 874
Grant ID : -
Förderprogramm : -
Förderorganisation : German Research Foundation (DFG)

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Titel: NeuroImage
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Orlando, FL : Academic Press
Seiten: - Band / Heft: 172 Artikelnummer: - Start- / Endseite: 853 - 863 Identifikator: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166