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  Gastric-bypass surgery induced widespread neural plasticity of the obese human brain

Rullmann, M., Preusser, S., Poppitz, S., Heba, S., Hoyer, J., Schütz, T., et al. (2018). Gastric-bypass surgery induced widespread neural plasticity of the obese human brain. NeuroImage, 172, 853-863. doi:10.1016/j.neuroimage.2017.10.062.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-3366-A Version Permalink: http://hdl.handle.net/21.11116/0000-0003-9666-1
Genre: Journal Article

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 Creators:
Rullmann, Michael1, 2, 3, 4, Author              
Preusser, Sven3, Author              
Poppitz, Sindy1, 3, Author
Heba, Stefanie1, 5, 6, Author
Hoyer, Jana7, Author
Schütz, Tatjana1, 8, Author
Dietrich, Arne1, 8, Author
Mueller, Karsten9, Author              
Pleger, Burkhard1, 3, 4, 5, 6, Author              
Affiliations:
1Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
2Department of Nuclear Medicine, University of Leipzig, Germany, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
4Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany, ou_persistent22              
5Department of Neurology, University Hospital Bergmannsheil, Bochum, Germany, ou_persistent22              
6Integration and Representation of Sensory Processes, Ruhr University, Bochum, Germany, ou_persistent22              
7Department of Psychology, TU Dresden, Germany, ou_persistent22              
8Department of Bariatric Surgery, University Hospital Leipzig, Germany, ou_persistent22              
9Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              

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Free keywords: Magnetic resonance imaging; Gray matter density; White matter density; White matter diffusion; Amplitudes of low frequency fluctuations; ALFF; Regional homogeneity; ReHo; Brain plasticity; Body weight; Bariatric surgery; Gastric-bypass surgery
 Abstract: Bariatric surgery has become the gold standard for the treatment of morbid obesity (body mass index (BMI) ≥ 40 kg/m2), but only few studies investigated its plastic influences on the obese brain. In this longitudinal study, we combined structural and functional magnetic resonance brain imaging (MRI) in 27 patients (BMI 47.8 ± 5.5 kg/m2) undergoing gastric-bypass surgery and 14 non-obese matched controls (BMI 24.7 ± 3.4 kg/m2). Over the first year after surgery, patients presented widespread changes in white matter density (WMD) as well as gray matter density (GMD) in the cerebral cortex of all lobes, subcortical structures, the brainstem as well as the cerebellum, but no changes in white matter water diffusivity throughout the brain. Voxel-by-voxel regression analyses revealed that all GMD and WMD changes were well associated with elevated regional homogeneity of spontaneous neural activity (ReHo) in blood-oxygenation level-dependent signals. Spatial-temporal integration of structural and functional MRI suggests that gastric-bypass surgery induces widespread plastic changes in brain structure that concurrently homogenizes the functional profile of the cortex, subcortical regions as well as white matter structures.

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Language(s): eng - English
 Dates: 2017-06-222017-10-272017-10-282018-05-15
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2017.10.062
PMID: 29107772
Other: Epub 2017
 Degree: -

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Project name : -
Grant ID : 01E01001
Funding program : -
Funding organization : IFB Adiposity Diseases, German Federal Ministry of Education and Research (BMBF)
Project name : Obesity Mechanisms / SFB 1052
Grant ID : -
Funding program : -
Funding organization : German Research Foundation (DFG)
Project name : Integration and Representation of Sensory Processes / SFB 874
Grant ID : -
Funding program : -
Funding organization : German Research Foundation (DFG)

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Title: NeuroImage
Source Genre: Journal
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Affiliations:
Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 172 Sequence Number: - Start / End Page: 853 - 863 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166