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  Increased striatal dopamine synthesis capacity in gambling addiction

van Holst, R. J., Sescousse, G., Janssen, L., Janssen, M., Berry, A. S., Jagust, W. J., et al. (2018). Increased striatal dopamine synthesis capacity in gambling addiction. Biological Psychiatry, 83(12), 1036-1043. doi:10.1016/j.biopsych.2017.06.010.

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Genre: Zeitschriftenartikel

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 Urheber:
van Holst, Ruth J.1, 2, Autor
Sescousse, Guillaume1, Autor
Janssen, Lieneke1, Autor           
Janssen, Marcel3, Autor
Berry, Anne S.4, Autor
Jagust, William J.4, Autor
Cools, Roshan1, 5, Autor
Affiliations:
1Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands, ou_persistent22              
2Department of Psychiatry, Academic Medical Center (AMC), University of Amsterdam, the Netherlands, ou_persistent22              
3Department of Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands, ou_persistent22              
4Helen Wills Neuroscience Institute, University of California, Berkeley, CA, ou_persistent22              
5Department of Psychiatry, Radboud University Medical Center, Nijmegen, the Netherlands, ou_persistent22              

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Schlagwörter: Addiction; Dopamine; [18F]DOPA; Gambling; Neuroimaging; Reward
 Zusammenfassung: Background

The hypothesis that dopamine plays an important role in the pathophysiology of pathological gambling is pervasive. However, there is little to no direct evidence for a categorical difference between pathological gamblers and healthy control subjects in terms of dopamine transmission in a drug-free state. Here we provide evidence for this hypothesis by comparing dopamine synthesis capacity in the dorsal and ventral parts of the striatum in 13 pathological gamblers and 15 healthy control subjects.
Methods

This was achieved using [18F]fluoro-levo-dihydroxyphenylalanine dynamic positron emission tomography scans and striatal regions of interest that were hand-drawn based on visual inspection of individual structural magnetic resonance imaging scans.
Results

Our results show that dopamine synthesis capacity was increased in pathological gamblers compared with healthy control subjects. Dopamine synthesis was 16% higher in the caudate body, 17% higher in the dorsal putamen, and 17% higher in the ventral striatum in pathological gamblers compared with control subjects. Moreover, dopamine synthesis capacity in the dorsal putamen and caudate head was positively correlated with gambling distortions in pathological gamblers.
Conclusions

Taken together, these results provide empirical evidence for increased striatal dopamine synthesis in pathological gambling.

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Sprache(n): eng - English
 Datum: 2017-05-152017-01-202017-06-012017-06-162018-06-15
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1016/j.biopsych.2017.06.010
PMID: 28728675
Anderer: Epub 2017
 Art des Abschluß: -

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Projektname : -
Grant ID : 446.11.025
Förderprogramm : Rubicon Grant
Förderorganisation : Netherlands Organisation for Scientific Research (NWO)
Projektname : -
Grant ID : 016.155.218
Förderprogramm : Veni Grant
Förderorganisation : Netherlands Organisation for Scientific Research (NWO)
Projektname : -
Grant ID : 2015/24762
Förderprogramm : Vici Grant
Förderorganisation : Netherlands Organisation for Scientific Research (NWO)
Projektname : -
Grant ID : -
Förderprogramm : James McDonnell scholar award
Förderorganisation : James S. McDonnell Foundation

Quelle 1

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Titel: Biological Psychiatry
  Andere : Biol. Psychiatry
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: New York : Elsevier
Seiten: - Band / Heft: 83 (12) Artikelnummer: - Start- / Endseite: 1036 - 1043 Identifikator: ISSN: 0006-3223
CoNE: https://pure.mpg.de/cone/journals/resource/954925384111