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  Increased striatal dopamine synthesis capacity in gambling addiction

van Holst, R. J., Sescousse, G., Janssen, L., Janssen, M., Berry, A. S., Jagust, W. J., & Cools, R. (2018). Increased striatal dopamine synthesis capacity in gambling addiction. Biological Psychiatry, 83(12), 1036-1043. doi:10.1016/j.biopsych.2017.06.010.

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アイテムのパーマリンク: https://hdl.handle.net/11858/00-001M-0000-002E-368D-9 版のパーマリンク: https://hdl.handle.net/21.11116/0000-0003-9E32-3
資料種別: 学術論文

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作成者

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 作成者:
van Holst, Ruth J.1, 2, 著者
Sescousse, Guillaume1, 著者
Janssen, Lieneke1, 著者           
Janssen, Marcel3, 著者
Berry, Anne S.4, 著者
Jagust, William J.4, 著者
Cools, Roshan1, 5, 著者
所属:
1Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands, ou_persistent22              
2Department of Psychiatry, Academic Medical Center (AMC), University of Amsterdam, the Netherlands, ou_persistent22              
3Department of Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands, ou_persistent22              
4Helen Wills Neuroscience Institute, University of California, Berkeley, CA, ou_persistent22              
5Department of Psychiatry, Radboud University Medical Center, Nijmegen, the Netherlands, ou_persistent22              

内容説明

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キーワード: Addiction; Dopamine; [18F]DOPA; Gambling; Neuroimaging; Reward
 要旨: Background

The hypothesis that dopamine plays an important role in the pathophysiology of pathological gambling is pervasive. However, there is little to no direct evidence for a categorical difference between pathological gamblers and healthy control subjects in terms of dopamine transmission in a drug-free state. Here we provide evidence for this hypothesis by comparing dopamine synthesis capacity in the dorsal and ventral parts of the striatum in 13 pathological gamblers and 15 healthy control subjects.
Methods

This was achieved using [18F]fluoro-levo-dihydroxyphenylalanine dynamic positron emission tomography scans and striatal regions of interest that were hand-drawn based on visual inspection of individual structural magnetic resonance imaging scans.
Results

Our results show that dopamine synthesis capacity was increased in pathological gamblers compared with healthy control subjects. Dopamine synthesis was 16% higher in the caudate body, 17% higher in the dorsal putamen, and 17% higher in the ventral striatum in pathological gamblers compared with control subjects. Moreover, dopamine synthesis capacity in the dorsal putamen and caudate head was positively correlated with gambling distortions in pathological gamblers.
Conclusions

Taken together, these results provide empirical evidence for increased striatal dopamine synthesis in pathological gambling.

資料詳細

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言語: eng - English
 日付: 2017-05-152017-01-202017-06-012017-06-162018-06-15
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: 査読あり
 識別子（DOI, ISBNなど）: DOI: 10.1016/j.biopsych.2017.06.010
PMID: 28728675
その他: Epub 2017
 学位: -

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訴訟

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Project information

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Project name : -
Grant ID : 446.11.025
Funding program : Rubicon Grant
Funding organization : Netherlands Organisation for Scientific Research (NWO)
Project name : -
Grant ID : 016.155.218
Funding program : Veni Grant
Funding organization : Netherlands Organisation for Scientific Research (NWO)
Project name : -
Grant ID : 2015/24762
Funding program : Vici Grant
Funding organization : Netherlands Organisation for Scientific Research (NWO)
Project name : -
Grant ID : -
Funding program : James McDonnell scholar award
Funding organization : James S. McDonnell Foundation

出版物 1

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出版物名: Biological Psychiatry
  その他 : Biol. Psychiatry
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: New York : Elsevier
ページ: - 巻号: 83 (12) 通巻号: - 開始・終了ページ: 1036 - 1043 識別子（ISBN, ISSN, DOIなど）: ISSN: 0006-3223
CoNE: https://pure.mpg.de/cone/journals/resource/954925384111