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  Abnormal modulation of reward versus punishment learning by a dopamine D2-receptor antagonist in pathological gamblers

Janssen, L., Sescousse, G., Hashemi, M. M., Timmer, M. H. M., ter Huurne, N. P., Geurts, D. E. M., et al. (2015). Abnormal modulation of reward versus punishment learning by a dopamine D2-receptor antagonist in pathological gamblers. Psychopharmacology, 232(18), 3345-3353. doi:10.1007/s00213-015-3986-y.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-36C5-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-77CA-4
Genre: Journal Article

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Janssen_2015.pdf (Publisher version), 474KB
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 Creators:
Janssen, Lieneke1, Author              
Sescousse, Guillaume1, Author
Hashemi, Mahur Melina1, Author
Timmer, Monique Harmina Maria1, Author
ter Huurne, Niels Peter1, Author
Geurts, Dirk Everdina Maria1, Author
Cools, Roshan1, Author
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1External Organizations, ou_persistent22              

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Free keywords: Pathological gambling; Dopamine; Reversal learning; Sulpiride; D2 antagonist
 Abstract: Rationale Pathological gambling has been associated with dopamine transmission abnormalities, in particular dopamine D2-receptor deficiency, and reversal learning deficits. Moreover, pervasive theoretical accounts suggest a key role for dopamine in reversal learning. However, there is no empirical evidence for a direct link between dopamine, reversal learning and pathological gambling. Objective The aim of the present study is to triangulate dopamine, reversal learning, and pathological gambling. Methods Here, we assess the hypothesis that pathological gambling is accompanied by dopamine-related problems with learning from reward and punishment by investigating effects of the dopamine D2-receptor antagonist sulpiride (400 mg) on reward- and punishment-based reversal learning in 18 pathological gamblers and 22 healthy controls, using a placebo-controlled, double-blind, counter-balanced design. Results In line with previous studies, blockade of D2 receptors with sulpiride impaired reward versus punishment reversal learning in controls. By contrast, sulpiride did not have any outcome-specific effects in gamblers. Conclusion These data demonstrate that pathological gambling is associated with a dopamine-related anomaly in reversal learning from reward and punishment.

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Language(s): eng - English
 Dates: 2015-04-222015-06-012015-06-202015-09
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1007/s00213-015-3986-y
PMID: 26092311
PMC: PMC4537492
Other: Epub 2015
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Title: Psychopharmacology
Source Genre: Journal
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Publ. Info: Heidelberg : Springer-Verlag
Pages: - Volume / Issue: 232 (18) Sequence Number: - Start / End Page: 3345 - 3353 Identifier: ISSN: 0033-3158
CoNE: https://pure.mpg.de/cone/journals/resource/954925436478