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  The role of macrophages within microenvironment in a lung cancer development and progression

Brčić, L., Opašić, L., & Popper, H. (2017). The role of macrophages within microenvironment in a lung cancer development and progression. In J. Haybaeck (Ed.), Mechanisms of Molecular Carcinogenesis – Volume 1 (pp. 271-285). Cham: Springer Nature. doi:10.1007/978-3-319-53659-0_17.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-3786-F Version Permalink: http://hdl.handle.net/21.11116/0000-0004-04BD-3
Genre: Book Chapter

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 Creators:
Brčić, L., Author
Opašić, L.1, Author              
Popper, H., Author
Affiliations:
1Department Evolutionary Theory, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445641              

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Free keywords: Tumor microenvironment; Lung cancer; M1 macrophages; M2 macrophages; Tumor-associated macrophages
 Abstract: Lung cancer, including carcinogenesis and therapy, is one of the main research focuses today. One of the main reasons for that is the very high mortality rate of patients with lung cancer. Cancer tissue is very heterogeneous, consisting of malignant tumor cells with many different cell types, proteins, and signaling molecules, all together forming the tumor microenvironment. The concept that tumor development is primarily based on mutations has been reapproached from the side of interaction between immune cells of the host, tumor cells, and tumor microenvironment. All components of the cancer microenvironment interact with each other and with tumor cells in a complex manner, both promoting tumor cell growth and development, as well as suppressing it. This interplay is very complicated and today still not completely understood. The most prevalent cells among leukocytes in the cancer microenvironment are macrophages. These are called tumor-associated macrophages and are still very difficult to differentiate and identify by single markers. However, it is clear that they have a very important role in tumor development and progression in lung cancer, as in many other cancers. In patients with lung carcinoma, there is a correlation between tumorassociated macrophages and prognosis, although not uniform. © 2017, Springer International Publishing AG.

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Language(s): eng - English
 Dates: 2017-05-252017
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1007/978-3-319-53659-0_17
BibTex Citekey: Brčić2017271
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Title: Mechanisms of Molecular Carcinogenesis – Volume 1
Source Genre: Book
 Creator(s):
Haybaeck, Johannes1, Editor
Affiliations:
1 Department of Pathology, Medical Faculty, Otto von Guericke University , Magdeburg, Germany, ou_persistent22            
Publ. Info: Cham : Springer Nature
Pages: 15 Volume / Issue: - Sequence Number: - Start / End Page: 271 - 285 Identifier: ISBN: 978-3-319-53657-6
ISBN: 978-3-319-53659-0
DOI: 10.1007/978-3-319-53659-0