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  Mitochondrial gene polymorphism is associated with gut microbial communities in mice

Hirose, M., Künstner, A., Schilf, P., Sünderhauf, A., Rupp, J., Jöhren, O., et al. (2017). Mitochondrial gene polymorphism is associated with gut microbial communities in mice. Scientific Reports, 7(1): 15293. doi:10.1038/s41598-017-15377-7.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-37B3-7 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-37B4-5
Genre: Journal Article

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 Creators:
Hirose, Misa, Author
Künstner, Axel1, Author              
Schilf, Paul, Author
Sünderhauf, Annika, Author
Rupp, Jan, Author
Jöhren, Olaf, Author
Schwaninger, Markus, Author
Sina, Christian, Author
Baines, John F.1, Author              
Ibrahim, Saleh M., Author
Affiliations:
1Guest Group Evolutionary Genomics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445638              

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Free keywords: Cell biology; Gastroenterology; Genetic interaction; Microbiology
 Abstract: Gut microbial communities are key mediators of health and disease and have the capacity to drive the pathogenesis of diverse complex diseases including metabolic and chronic inflammatory diseases as well as aging. Host genetics is also a major determinant of disease phenotypes, whereby two different genomes play a role, the nuclear (nDNA)-and mitochondrial genome (mtDNA). We investigated the impact of mutations in mtDNA on the gut microbiota using conplastic mouse strains exhibiting distinct mutations in their mtDNA on an identical nDNA. Each of three strain tested harbors a distinct gut microbiota, ranging from differences at the phylum-to operational taxonomic units level. The C57BL/6J-mt FVB/NJ strain, carrying a mutation in the mitochondrial ATP8 synthase gene, exhibits higher Firmicutes abundance than Bacteroidetes, indicating a possible indicative for metabolic dysfunctions. In line with this, the C57BL/6J-mt FVB/NJ displays a variety of different phenotypes, including increased susceptibility to metabolic-related and inflammatory disorders. Furthermore, we discuss the cross-talk between mitochondrial genome/mitochondria and commensal microbiota in relation to clinical phenotypes. In summary, we demonstrate that mutations in mtDNA lead to significant differences in the composition of gut microbial communities in mice. Such differences may facilitate the emergence of metabolic disease and therefore constitute potential therapeutic targets. © 2017 The Author(s).

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Language(s): eng - English
 Dates: 2017-08-072017-10-252017-11-102017
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
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Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: London, UK : Nature Publishing Group
Pages: 9 Volume / Issue: 7 (1) Sequence Number: 15293 Start / End Page: - Identifier: ISSN: 2045-2322
CoNE: /journals/resource/2045-2322