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  Modeling the contributions of chromosome segregation errors and aneuploidy to Saccharomyces hybrid sterility

Boynton, P. J., Janzen, T., & Greig, D. (2017). Modeling the contributions of chromosome segregation errors and aneuploidy to Saccharomyces hybrid sterility. Yeast, 85-98. doi:10.1002/yea.3282.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-584E-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-7E6F-7
Genre: Journal Article

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 Creators:
Boynton, Primrose J.1, Author              
Janzen, Thijs2, Author              
Greig, Duncan3, Author              
Affiliations:
1Max-Planck Research Group Experimental Evolution, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445640              
2Department Evolutionary Theory, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445641              
3External, ou_persistent22              

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Free keywords: hybrid; meiosis; postzygotic reproductive isolation; disomy; ascospore
 Abstract: Errors in meiosis can be important postzygotic barriers between different species. In Saccharomyces hybrids, chromosomal missegregation during meiosis I produces gametes with missing or extra chromosomes. Gametes with missing chromosomes are inviable, but we do not understand how extra chromosomes (disomies) influence hybrid gamete inviability. We designed a model predicting rates of missegregation in interspecific hybrid meioses assuming several different mechanisms of disomy tolerance, and compared predictions from the model with observations of sterility in hybrids between Saccharomyces yeast species. Sterility observations were consistent with the hypothesis that chromosomal missegregation causes hybrid sterility, and the model indicated that missegregation probabilities of 13-50 per chromosome can cause observed values of 90-99 hybrid sterility regardless of how cells tolerate disomies. Missing chromosomes in gametes are responsible for most infertility, but disomies may kill as many as 11 of the gametes produced by hybrids between Saccharomyces cerevisiae and Saccharomyces paradoxus. © 2017 John Wiley Sons, Ltd.

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Language(s): eng - English
 Dates: 2017-07-282017-09-192017-11-122017
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1002/yea.3282
BibTex Citekey: Boynton2017
 Degree: -

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Title: Yeast
Source Genre: Journal
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Publ. Info: New York, NY : John Wiley & Sons
Pages: 14 Volume / Issue: - Sequence Number: - Start / End Page: 85 - 98 Identifier: ISSN: 0749-503X
CoNE: /journals/resource/110990112651288_1