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  Whole-brain source-reconstructed MEG-data reveal reduced long-range synchronization in chronic schizophrenia

Hirvonen, J., Wibral, M., Palva, J. M., Singer, W., Uhlhaas, P., & Palva, S. (2017). Whole-brain source-reconstructed MEG-data reveal reduced long-range synchronization in chronic schizophrenia. eNeuro, 4(5): e0338-17.2017. doi:10.1523/ENEURO.0338-17.2017.

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Hirvonen_2017_Whole-BrainSource-Reconstructed.pdf (Publisher version), 3MB
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Hirvonen_2017_Whole-BrainSource-Reconstructed.pdf
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2017
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Copyright © 2017 Hirvonen et al.

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OA-Status:
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 Creators:
Hirvonen, Jonni, Author
Wibral, Michael, Author
Palva, J. Matias, Author
Singer, Wolf1, 2, Author                 
Uhlhaas, Peter, Author
Palva, Satu, Author
Affiliations:
1Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society, Deutschordenstr. 46, 60528 Frankfurt, DE, ou_2074314              
2Singer Lab, Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society, Deutschordenstraße 46, 60528 Frankfurt, DE, ou_3381220              

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Free keywords: Adult Brain/*physiopathology Chronic Disease *Cortical Synchronization Female Gamma Rhythm Humans *Magnetoencephalography Male Psychiatric Status Rating Scales Schizophrenia/*physiopathology Severity of Illness Index *meg *oscillation *perception *schizophrenia *synchronization
 Abstract: Current theories of schizophrenia (ScZ) posit that the symptoms and cognitive dysfunctions arise from a dysconnection syndrome. However, studies that have examined this hypothesis with physiological data at realistic time scales are so far scarce. The current study employed a state-of-the-art approach using Magnetoencephalography (MEG) to test alterations in large-scale phase synchronization in a sample of n = 16 chronic ScZ patients, 10 males and n = 19 healthy participants, 10 males, during a perceptual closure task. We identified large-scale networks from source reconstructed MEG data using data-driven analyses of neuronal synchronization. Oscillation amplitudes and interareal phase-synchronization in the 3-120 Hz frequency range were estimated for 400 cortical parcels and correlated with clinical symptoms and neuropsychological scores. ScZ patients were characterized by a reduction in gamma-band (30-120 Hz) oscillation amplitudes that was accompanied by a pronounced deficit in large-scale synchronization at gamma-band frequencies. Synchronization was reduced within visual regions as well as between visual and frontal cortex and the reduction of synchronization correlated with elevated clinical disorganization. Accordingly, these data highlight that ScZ is associated with a profound disruption of transient synchronization, providing critical support for the notion that core aspect of the pathophysiology arises from an impairment in coordination of distributed neural activity.

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 Dates: 2017-10-09
 Publication Status: Published online
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1523/ENEURO.0338-17.2017
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Title: eNeuro
Source Genre: Journal
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Publ. Info: Society for Neuroscience
Pages: - Volume / Issue: 4 (5) Sequence Number: e0338-17.2017 Start / End Page: - Identifier: ISSN: 2373-2822
CoNE: https://pure.mpg.de/cone/journals/resource/106249492X