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  Alterations in functional cortical hierarchy in hemiparkinsonian rats

Javor-Duray, B. N., Vinck, M., van der Roest, M., Bezard, E., Berendse, H. W., Boraud, T., & Voorn, P. (2017). Alterations in functional cortical hierarchy in hemiparkinsonian rats. Journal of Neuroscience. doi:10.1523/JNEUROSCI.3257-16.2017.

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アイテムのパーマリンク: https://hdl.handle.net/11858/00-001M-0000-002E-7E43-4 版のパーマリンク: https://hdl.handle.net/11858/00-001M-0000-002E-7E44-2
資料種別: 学術論文
その他のタイトル : Journal of Neuroscience

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 作成者:
Javor-Duray, B. N., 著者
Vinck, M.1, 著者
van der Roest, M., 著者
Bezard, E., 著者
Berendse, H. W., 著者
Boraud, T., 著者
Voorn, P., 著者
所属:
1Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society, Deutschordenstr. 46, 60528 Frankfurt, DE, ou_2074314              

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 要旨: Parkinson's disease and experimentally induced hemiparkinsonism are characterized by increased beta-synchronization between cortical and subcortical areas. This change in beta-connectivity might reflect either a symmetric increase in interareal influences or asymmetric changes in directed influences among brain areas. We assessed patterns of functional and directed connectivity within and between striatum and six cortical sites in each hemisphere of the hemiparkinsonian rat model. Local field potentials were recorded in resting and walking states, before and after unilateral 6-hydroxydopamine lesion. The hemiparkinsonian state was characterized by increased oscillatory activity in the 20-40 Hz range in resting and walking states, and increased interhemispheric coupling (phase lag index) that was more widespread at rest than during walking. Spectral Granger-causality analysis revealed that the change in symmetric functional connectivity comprised profound reorganization of hierarchical organization and directed influence patterns. First, in the lesioned hemisphere, the more anterior, non-primary motor areas located at the top of the cortical hierarchy (i.e. receiving many directed influences) tended to increase their directed influence onto the posterior primary motor and somatosensory areas. This enhanced influence of "higher" areas may be related to the loss of motor control due to the 6-OHDA lesion. Second, the drive from the non-lesioned towards the lesioned hemisphere (in particular to striatum) increased, most prominently during walking. The nature of these adaptations

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 日付: 2017
 出版の状態: 出版
 ページ: -
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 査読: -
 識別子（DOI, ISBNなど）: URI: http://www.ncbi.nlm.nih.gov/pubmed/28687605
その他: 1579
DOI: 10.1523/JNEUROSCI.3257-16.2017
 学位: -

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出版物名: Journal of Neuroscience
  出版物の別名 : The Journal of neuroscience : the official journal of the Society for Neuroscience
種別: 学術雑誌
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出版社, 出版地: -
ページ: - 巻号: - 通巻号: - 開始・終了ページ: - 識別子（ISBN, ISSN, DOIなど）: ISBN: 1529-2401 (Electronic)0270-6474 (Linking)