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  Molecular simulations of the ribosome and associated translation factors.

Bock, L. V., Kolar, M. H., & Grubmüller, H. (2018). Molecular simulations of the ribosome and associated translation factors. Current Opinion in Structural Biology, 49, 27-35. doi:10.1016/j.sbi.2017.11.003.

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Bock, L. V.1, Author           
Kolar, M. H.1, Author           
Grubmüller, H.1, Author           
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1Department of Theoretical and Computational Biophysics, MPI for biophysical chemistry, Max Planck Society, ou_578631              

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 Abstract: The ribosome is a macromolecular complex which is responsible for protein synthesis in all living cells according to their transcribed genetic information. Using X-ray crystallography and, more recently, cryo-electron microscopy (cryo-EM), the structure of the ribosome was resolved at atomic resolution in many functional and conformational states. Molecular dynamics simulations have added information on dynamics and energetics to the available structural information, thereby have bridged the gap to the kinetics obtained from single-molecule and bulk experiments. Here, we review recent computational studies that brought notable insights into ribosomal structure and function.

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Language(s): eng - English
 Dates: 2017-12-012018-04
 Publication Status: Issued
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 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.sbi.2017.11.003
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Title: Current Opinion in Structural Biology
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Pages: - Volume / Issue: 49 Sequence Number: - Start / End Page: 27 - 35 Identifier: -