Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
  Developmental Dysfunction of VIP Interneurons Impairs Cortical Circuits

Batista-Brito, R., Vinck, M., Ferguson, K. A., Chang, J. T., Laubender, D., Lur, G., et al. (2017). Developmental Dysfunction of VIP Interneurons Impairs Cortical Circuits. Neuron, 95. doi:10.1016/j.neuron.2017.07.034.

Item is

Basisdaten

einblenden: ausblenden:
Genre: Zeitschriftenartikel
Alternativer Titel : Neuron

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Batista-Brito, R., Autor
Vinck, M.1, Autor
Ferguson, K. A., Autor
Chang, J. T., Autor
Laubender, D., Autor
Lur, G., Autor
Mossner, J. M., Autor
Hernandez, V. G., Autor
Ramakrishnan, C., Autor
Deisseroth, K., Autor
Higley, M. J., Autor
Cardin, J. A., Autor
Affiliations:
1Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society, Deutschordenstr. 46, 60528 Frankfurt, DE, ou_2074314              

Inhalt

einblenden:
ausblenden:
Schlagwörter: Action Potentials/physiology Animals Animals, Newborn Calcium/metabolism Cerebral Cortex/*pathology Developmental Disabilities/*genetics/*pathology Disease Models, Animal Gene Expression Regulation, Developmental/*genetics Homeodomain Proteins/genetics/metabolism In Vitro Techniques Interneurons/metabolism/*pathology Mice Mice, Transgenic Patch-Clamp Techniques Photic Stimulation Receptor, ErbB-4/genetics/metabolism Signal Detection, Psychological/physiology Somatostatin/genetics/metabolism Spectrum Analysis Vasoactive Intestinal Peptide/genetics/*metabolism Visual Pathways/growth & development/pathology
 Zusammenfassung: GABAergic interneurons play important roles in cortical circuit development. However, there are multiple populations of interneurons and their respective developmental contributions remain poorly explored. Neuregulin 1 (NRG1) and its interneuron-specific receptor ERBB4 are critical genes for interneuron maturation. Using a conditional ErbB4 deletion, we tested the role of vasoactive intestinal peptide (VIP)-expressing interneurons in the postnatal maturation of cortical circuits in vivo. ErbB4 removal from VIP interneurons during development leads to changes in their activity, along with severe dysregulation of cortical temporal organization and state dependence. These alterations emerge during adolescence, and mature animals in which VIP interneurons lack ErbB4 exhibit reduced cortical responses to sensory stimuli and impaired sensory learning. Our data support a key role for VIP interneurons in cortical circuit development and suggest a possible contribution to pathophysiology in neurodevelopmental disorders. These findings provide a new perspective on the role of GABAergic interneuron diversity in cortical development. VIDEO ABSTRACT.

Details

einblenden:
ausblenden:
Sprache(n):
 Datum: 2017
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: Neuron
  Alternativer Titel : Neuron
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: 884-895 e9 Band / Heft: 95 Artikelnummer: - Start- / Endseite: - Identifikator: ISBN: 1097-4199 (Electronic)0896-6273 (Linking)