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  Developmental dysfunction of VIP interneurons impairs cortical circuits

Batista-Brito, R., Vinck, M., Ferguson, K. A., Chang, J. T., Laubender, D., Lur, G., et al. (2017). Developmental dysfunction of VIP interneurons impairs cortical circuits. Neuron, 95(4), 884-895.e9. doi:10.1016/j.neuron.2017.07.034.

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Batista-Brito_2017_DevelopmentalDysfunction.pdf (Publisher version), 4MB
 
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Batista-Brito_2017_DevelopmentalDysfunction.pdf
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 Creators:
Batista-Brito, Renata, Author
Vinck, Martin1, 2, Author                 
Ferguson, Katie A., Author
Chang, Jeremy T., Author
Laubender, David, Author
Lur, Gyorgy, Author
Mossner, James M., Author
Hernandez, Victoria G., Author
Ramakrishnan, Charu, Author
Deisseroth, Karl, Author
Higley, Michael J., Author
Cardin, Jessica A., Author
Affiliations:
1Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society, Deutschordenstr. 46, 60528 Frankfurt, DE, ou_2074314              
2Vinck Lab, Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society, Deutschordenstraße 46, 60528 Frankfurt, DE, ou_3381242              

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Free keywords: Action Potentials/physiology Animals Animals, Newborn Calcium/metabolism Cerebral Cortex/*pathology Developmental Disabilities/*genetics/*pathology Disease Models, Animal Gene Expression Regulation, Developmental/*genetics Homeodomain Proteins/genetics/metabolism In Vitro Techniques Interneurons/metabolism/*pathology Mice Mice, Transgenic Patch-Clamp Techniques Photic Stimulation Receptor, ErbB-4/genetics/metabolism Signal Detection, Psychological/physiology Somatostatin/genetics/metabolism Spectrum Analysis Vasoactive Intestinal Peptide/genetics/*metabolism Visual Pathways/growth & development/pathology
 Abstract: GABAergic interneurons play important roles in cortical circuit development. However, there are multiple populations of interneurons and their respective developmental contributions remain poorly explored. Neuregulin 1 (NRG1) and its interneuron-specific receptor ERBB4 are critical genes for interneuron maturation. Using a conditional ErbB4 deletion, we tested the role of vasoactive intestinal peptide (VIP)-expressing interneurons in the postnatal maturation of cortical circuits in vivo. ErbB4 removal from VIP interneurons during development leads to changes in their activity, along with severe dysregulation of cortical temporal organization and state dependence. These alterations emerge during adolescence, and mature animals in which VIP interneurons lack ErbB4 exhibit reduced cortical responses to sensory stimuli and impaired sensory learning. Our data support a key role for VIP interneurons in cortical circuit development and suggest a possible contribution to pathophysiology in neurodevelopmental disorders. These findings provide a new perspective on the role of GABAergic interneuron diversity in cortical development. VIDEO ABSTRACT.

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 Dates: 2017-08-162017-08-16
 Publication Status: Issued
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 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.neuron.2017.07.034
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Title: Neuron
  Alternative Title : Neuron
Source Genre: Journal
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Pages: - Volume / Issue: 95 (4) Sequence Number: - Start / End Page: 884 - 895.e9 Identifier: ISBN: 1097-4199 (Electronic)0896-6273 (Linking)