English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Region and cell-type resolved quantitative proteomic map of the human heart

Doll, S., Dressen, M., Geyer, P. E., Itzhak, D. N., Braun, C., Doppler, S. A., et al. (2017). Region and cell-type resolved quantitative proteomic map of the human heart. Nature Communications, 8: 1469. doi:10.1038/s41467-017-01747-2.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-89B0-A Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-89B1-8
Genre: Journal Article

Files

show Files
hide Files
:
Doll_et_al-2017-Nature_Communications.pdf (Publisher version), 3MB
Name:
Doll_et_al-2017-Nature_Communications.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License.

Locators

show
hide
Description:
-

Creators

show
hide
 Creators:
Doll, Sophia1, Author              
Dressen, Martina2, Author
Geyer, Philipp E.1, Author              
Itzhak, Daniel N.1, Author              
Braun, Christian2, Author
Doppler, Stefanie A.2, Author
Meier, Florian1, Author              
Deutsch, Marcus-Andre2, Author
Lahm, Harald2, Author
Lange, Ruediger2, Author
Krane, Markus2, Author
Mann, Matthias1, Author              
Affiliations:
1Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565159              
2external, ou_persistent22              

Content

show
hide
Free keywords: ATRIAL-FIBRILLATION; MYOCARDIAL-INFARCTION; GENE-EXPRESSION; MESSENGER-RNA; VALVE DISEASE; COPY-NUMBER; MYOSIN; MUSCLE; FIBROBLASTS; MECHANISMSScience & Technology - Other Topics;
 Abstract: The heart is a central human organ and its diseases are the leading cause of death worldwide, but an in-depth knowledge of the identity and quantity of its constituent proteins is still lacking. Here, we determine the healthy human heart proteome by measuring 16 anatomical regions and three major cardiac cell types by high-resolution mass spectrometry-based proteomics. From low microgram sample amounts, we quantify over 10,700 proteins in this high dynamic range tissue. We combine copy numbers per cell with protein organellar assignments to build a model of the heart proteome at the subcellular level. Analysis of cardiac fibroblasts identifies cellular receptors as potential cell surface markers. Application of our heart map to atrial fibrillation reveals individually distinct mitochondrial dysfunctions. The heart map is available at maxqb. biochem. mpg. de as a resource for future analyses of normal heart function and disease.

Details

show
hide
Language(s): eng - English
 Dates: 2017-11-13
 Publication Status: Published online
 Pages: 13
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 8 Sequence Number: 1469 Start / End Page: - Identifier: ISSN: 2041-1723
CoNE: /journals/resource/2041-1723