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  Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production

Wewer Albrechtsen, N. J., Kuhre, R. E., Hornburg, D., Jensen, C. Z., Hornum, M., Dirksen, C., et al. (2017). Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production. Cell Reports, 21(6), 1452-1460. doi:10.1016/j.celrep.2017.10.034.

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© 2017 The Author(s). Open Access funded by European Molecular Biology Laboratory
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 Creators:
Wewer Albrechtsen, Nicolai J.1, Author              
Kuhre, Rune E.2, Author
Hornburg, Daniel1, Author              
Jensen, Christian Z.2, Author
Hornum, Mads2, Author
Dirksen, Carsten2, Author
Svane, Maria2, Author
Gasbjerg, Laerke S.2, Author
Jorgensen, Nils B.2, Author
Gabe, Maria N.2, Author
Balk-Moller, Emilie2, Author
Albrechtsen, Reidar2, Author
Winther-Sorensen, Marie2, Author
Galsgaard, Katrine D.2, Author
Meissner, Felix3, Author              
Jorsal, Tina2, Author
Lund, Asger2, Author
Vilsboll, Tina2, Author
Eliasen, Rasmus2, Author
Bojsen-Moller, Kirstine N.2, Author
Idorn, Thomas2, AuthorDeacon, Carolyn F.2, AuthorKnop, Filip K.2, AuthorRosenkilde, Mette M.2, AuthorHartmann, Bolette2, AuthorFeldt-Rasmussen, Bo2, AuthorMann, Matthias1, Author              Madsbad, Sten2, AuthorHolst, Jens J.2, Author more..
Affiliations:
1Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565159              
2external, ou_persistent22              
3Meissner, Felix / Experimental Systems Immunology, Max Planck Institute of Biochemistry, Max Planck Society, ou_2149678              

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Free keywords: GASTRIC BYPASS-SURGERY; CELLS; PROGLUCAGON; PEPTIDE-1; PLASMACell Biology;
 Abstract: Glucagon is secreted from pancreatic a cells, and hypersecretion (hyperglucagonemia) contributes to diabetic hyperglycemia. Molecular heterogeneity in hyperglucagonemia is poorly investigated. By screening human plasma using high-resolution-proteomics, we identified several glucagon variants, among which proglucagon 1-61 (PG 1-61) appears to be the most abundant form. PG 1-61 is secreted in subjects with obesity, both before and after gastric bypass surgery, with protein and fat as the main drivers for secretion before surgery, but glucose after. Studies in hepatocytes and in b cells demonstrated that PG 1-61 dose-dependently increases levels of cAMP, through the glucagon receptor, and increases insulin secretion and protein levels of enzymes regulating glycogenolysis and gluconeogenesis. In rats, PG 1-61 increases blood glucose and plasma insulin and decreases plasma levels of amino acids in vivo. We conclude that glucagon variants, such as PG 1-61, may contribute to glucose regulation by stimulating hepatic glucose production and insulin secretion.

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Language(s): eng - English
 Dates: 2017-11-072017
 Publication Status: Published in print
 Pages: 9
 Publishing info: -
 Table of Contents: -
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Title: Cell Reports
Source Genre: Journal
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Publ. Info: Maryland Heights, MO : Cell Press
Pages: - Volume / Issue: 21 (6) Sequence Number: - Start / End Page: 1452 - 1460 Identifier: Other: 2211-1247
CoNE: https://pure.mpg.de/cone/journals/resource/2211-1247