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  A Primer on Concepts and Applications of Proteomics in Neuroscience

Hosp, F., & Mann, M. (2017). A Primer on Concepts and Applications of Proteomics in Neuroscience. Neuron, 96(3), 558-571. doi:10.1016/j.neuron.2017.09.025.

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 Creators:
Hosp, Fabian1, Author              
Mann, Matthias1, Author              
Affiliations:
1Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565159              

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Free keywords: QUANTITATIVE INTERACTION PROTEOMICS; EXCITATORY SYNAPSE DEVELOPMENT; SPECTROMETRY-BASED PROTEOMICS; REVERSED-PHASE FRACTIONATION; PROTEIN-COUPLED RECEPTORS; IMAGING MASS-SPECTROMETRY; MOUSE-BRAIN PROTEOME; ALZHEIMERS-DISEASE; IN-VIVO; POSTTRANSLATIONAL MODIFICATIONSNeurosciences & Neurology;
 Abstract: The enormous complexity of the central nervous system has impeded its systemic exploration for decades but powerful "omic'' technologies are now pushing forward the frontiers of neuroscience research at an increasing pace. This Primer reviews the most recent progress in mass spectrometry (MS)-based proteomics, focusing on the analysis of whole proteomes, protein-based interactions, and post-translational modifications. We also discuss how advanced workflows help to unravel spatial, regulatory, and temporal aspects of neuronal systems. These tools and approaches have already led to detailed and quantitative proteomic maps of the brain and its signaling architecture, generating new insights into health and disease. We predict that these new approaches will also accelerate biomarker discovery and contribute to novel therapeutics for neurodegenerative and other brain-related diseases.

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Language(s): eng - English
 Dates: 2017
 Publication Status: Published in print
 Pages: 14
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Degree: -

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Project name : Synergy Grant “ToPAG - Toxic protein aggregation in neurodegeneration” (ERC-2012-SyG_318987-ToPAG)
Grant ID : 318987
Funding program : -
Funding organization : European Research Council

Source 1

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Title: Neuron
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 96 (3) Sequence Number: - Start / End Page: 558 - 571 Identifier: ISSN: 0896-6273
CoNE: https://pure.mpg.de/cone/journals/resource/954925560565