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  Quantitative MRI provides markers of intra-, inter-regional, and age-related differences in young adult cortical microstructure

Carey, D., Caprini, F., Allen, M., Lutti, A., Weiskopf, N., Rees, G., et al. (2018). Quantitative MRI provides markers of intra-, inter-regional, and age-related differences in young adult cortical microstructure. NeuroImage, 182, 429-440. doi:10.1016/j.neuroimage.2017.11.066.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-8812-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-4AC5-A
Genre: Journal Article

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 Creators:
Carey, Daniel1, 2, Author
Caprini, Francesco2, Author
Allen, Micah3, 4, Author
Lutti, Antoine3, 5, Author
Weiskopf, Nikolaus3, 6, Author              
Rees, Geraint3, 4, Author
Callaghan, Martina F.3, Author
Dick, Frederic2, 7, Author
Affiliations:
1The Irish Longitudinal Study on Ageing, Trinity College Dublin, Ireland, ou_persistent22              
2Centre for Brain and Cognitive Development, Birkbeck, University of London, United Kingdom, ou_persistent22              
3Institute of Cognitive Neuroscience, University College London, United Kingdom, ou_persistent22              
4Wellcome Trust Centre for Neuroimaging, University College London, United Kingdom, ou_persistent22              
5Laboratoire de Recherche en Neuroimagerie (LREN), Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
6Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
7Birkbeck-UCL Centre for Neuroimaging, London, United Kingdom, ou_persistent22              

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Free keywords: Aging; Microstructure; Multi-parameter maps (MPM); Myelination; Quantitative MRI
 Abstract: Measuring the structural composition of the cortex is critical to understanding typical development, yet few investigations in humans have charted markers in vivo that are sensitive to tissue microstructural attributes. Here, we used a well-validated quantitative MR protocol to measure four parameters (R1, MT, R2*, PD*) that differ in their sensitivity to facets of the tissue microstructural environment (R1, MT: myelin, macromolecular content; R2*: myelin, paramagnetic ions, i.e., iron; PD*: free water content). Mapping these parameters across cortical regions in a young adult cohort (18-39 years, N = 93) revealed expected patterns of increased macromolecular content as well as reduced tissue water content in primary and primary adjacent cortical regions. Mapping across cortical depth within regions showed decreased expression of myelin and related processes - but increased tissue water content - when progressing from the grey/white to the grey/pial boundary, in all regions. Charting developmental change in cortical microstructure cross-sectionally, we found that parameters with sensitivity to tissue myelin (R1 & MT) showed linear increases with age across frontal and parietal cortex (change 0.5-1.0% per year). Overlap of robust age effects for both parameters emerged in left inferior frontal, right parietal and bilateral pre-central regions. Our findings afford an improved understanding of ontogeny in early adulthood and offer normative quantitative MR data for inter- and intra-cortical composition, which may be used as benchmarks in further studies.

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Language(s): eng - English
 Dates: 2017-10-192017-05-172017-11-292017-12-052018-11-15
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2017.11.066
PMID: 29203455
Other: Epub 2017
 Degree: -

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Project name : Non-invasive in vivo histology in health and disease using Magnetic Resonance Imaging (MRI) / HMRI
Grant ID : 616905
Funding program : FP7 (ERC-2013-CoG)
Funding organization : European Commission (EC)
Project name : -
Grant ID : 0915/Z/10/Z
Funding program : -
Funding organization : Wellcome Trust (WT)
Project name : -
Grant ID : 100227
Funding program : -
Funding organization : Wellcome Trust (WT)
Project name : Tracking Early Development: From Basic Science to Applications / TRACKDEV
Grant ID : 264301
Funding program : Funding Programme 7 (FP7)
Funding organization : European Commission (EC)

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Title: NeuroImage
Source Genre: Journal
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Affiliations:
Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 182 Sequence Number: - Start / End Page: 429 - 440 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166