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  Functional dissociation of stimulus intensity encoding and predictive coding of pain in the insula

Geuter, S., Boll, S., Eippert, F., & Büchel, C. (2017). Functional dissociation of stimulus intensity encoding and predictive coding of pain in the insula. eLife, 6: e24770. doi:10.7554/eLife.24770.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-896B-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-BD52-C
Genre: Journal Article

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 Creators:
Geuter, Stephan1, 2, 3, Author
Boll, Sabrina1, 4, Author
Eippert, Falk5, Author              
Büchel, Christian1, Author
Affiliations:
1Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, ou_persistent22              
2Institute of Cognitive Science, University of Colorado Boulder, CO , ou_persistent22              
3Department of Psychology and Neuroscience, University of Colorado Boulder, CO, ou_persistent22              
4Department of General Psychiatry, University Hospital Heidelberg, Germany, ou_persistent22              
5Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, United Kingdom, ou_persistent22              

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Free keywords: expectations; fMRI; human; neuroscience; pain; predictive coding; somatosensory perception
 Abstract: The computational principles by which the brain creates a painful experience from nociception are still unknown. Classic theories suggest that cortical regions either reflect stimulus intensity or additive effects of intensity and expectations, respectively. By contrast, predictive coding theories provide a unified framework explaining how perception is shaped by the integration of beliefs about the world with mismatches resulting from the comparison of these beliefs against sensory input. Using functional magnetic resonance imaging during a probabilistic heat pain paradigm, we investigated which computations underlie pain perception. Skin conductance, pupil dilation, and anterior insula responses to cued pain stimuli strictly followed the response patterns hypothesized by the predictive coding model, whereas posterior insula encoded stimulus intensity. This novel functional dissociation of pain processing within the insula together with previously observed alterations in chronic pain offer a novel interpretation of aberrant pain processing as disturbed weighting of predictions and prediction errors.

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Language(s): eng - English
 Dates: 2017-01-022017-05-182017-06-14
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.7554/eLife.24770
PMID: 28524817
PMC: PMC5470871
 Degree: -

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Project name : Spino-kortikale Interaktionen bei Schmerz und Schmerzmodulation / SFB 936 A06
Grant ID : -
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft (DFG)
Project name : Divided Metacognition: when epistemic norms conflict / DIVIDNORM
Grant ID : 269616
Funding program : Funding Programme 7
Funding organization : European Commission (EC)
Project name : -
Grant ID : GE 2774/1-1
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft (DFG)

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Title: eLife
Source Genre: Journal
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Publ. Info: Cambridge : eLife Sciences Publications
Pages: - Volume / Issue: 6 Sequence Number: e24770 Start / End Page: - Identifier: ISSN: 2050-084X
CoNE: /journals/resource/2050-084X