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  Direct evidence for spinal cord involvement in placebo analgesia

Eippert, F., Finsterbusch, J., Bingel, U., & Büchel, C. (2009). Direct evidence for spinal cord involvement in placebo analgesia. Science, 326(5951), 404-404. doi:10.1126/science.1180142.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-89B9-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-F99E-4
Genre: Journal Article

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 Creators:
Eippert, Falk1, Author              
Finsterbusch, Jürgen1, Author
Bingel, Ulrike1, Author
Büchel, Christian1, Author
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1External Organizations, ou_persistent22              

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 Abstract: Placebo analgesia is a prime example of the impact that psychological factors have on pain perception. We used functional magnetic resonance imaging of the human spinal cord to test the hypothesis that placebo analgesia results in a reduction of nociceptive processing in the spinal cord. In line with behavioral data that show decreased pain responses under placebo, pain-related activity in the spinal cord is strongly reduced under placebo. These results provide direct evidence for spinal inhibition as one mechanism of placebo analgesia and highlight that psychological factors can act on the earliest stages of pain processing in the central nervous system.

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Language(s): eng - English
 Dates: 2009-08-042009-09-172009-10-16
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1126/science.1180142
PMID: 19833962
 Degree: -

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Title: Science
Source Genre: Journal
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Publ. Info: Washington, D.C. : American Association for the Advancement of Science
Pages: - Volume / Issue: 326 (5951) Sequence Number: - Start / End Page: 404 - 404 Identifier: ISSN: 0036-8075
CoNE: /journals/resource/991042748276600_1