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  Intrinsically organized resting state networks in the human spinal cord

Kong, Y., Eippert, F., Beckmann, C. F., Andersson, J., Finsterbusch, J., Büchel, C., et al. (2014). Intrinsically organized resting state networks in the human spinal cord. Proceedings of the National Academy of Sciences of the United States of America, 111(50), 18067-18072. doi:10.1073/pnas.1414293111.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-89E4-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-7CDD-A
Genre: Journal Article

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 Creators:
Kong, Yazhuo1, Author
Eippert, Falk1, Author              
Beckmann, Christian F.1, Author
Andersson, Jesper1, Author
Finsterbusch, Jürgen1, Author
Büchel, Christian1, Author
Tracey, Irene1, Author
Brooks, Jonathan C. W.1, Author
Affiliations:
1External Organizations, ou_persistent22              

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Free keywords: fMRI; Spinal cord; Resting state; Connectivity; Networks
 Abstract: Spontaneous fluctuations in functional magnetic resonance imaging (fMRI) signals of the brain have repeatedly been observed when no task or external stimulation is present. These fluctuations likely reflect baseline neuronal activity of the brain and correspond to functionally relevant resting-state networks (RSN). It is not known however, whether intrinsically organized and spatially circumscribed RSNs also exist in the spinal cord, the brain’s principal sensorimotor interface with the body. Here, we use recent advances in spinal fMRI methodology and independent component analysis to answer this question in healthy human volunteers. We identified spatially distinct RSNs in the human spinal cord that were clearly separated into dorsal and ventral components, mirroring the functional neuroanatomy of the spinal cord and likely reflecting sensory and motor processing. Interestingly, dorsal (sensory) RSNs were separated into right and left components, presumably related to ongoing hemibody processing of somatosensory information, whereas ventral (motor) RSNs were bilateral, possibly related to commissural interneuronal networks involved in central pattern generation. Importantly, all of these RSNs showed a restricted spatial extent along the spinal cord and likely conform to the spinal cord’s functionally relevant segmental organization. Although the spatial and temporal properties of the dorsal and ventral RSNs were found to be significantly different, these networks showed significant interactions with each other at the segmental level. Together, our data demonstrate that intrinsically highly organized resting-state fluctuations exist in the human spinal cord and are thus a hallmark of the entire central nervous system.

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Language(s): eng - English
 Dates: 2014-07-272014-11-112014-12-16
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1073/pnas.1414293111
PMID: 25472845
PMC: PMC4273395
Other: Epub 2014
 Degree: -

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Title: Proceedings of the National Academy of Sciences of the United States of America
  Abbreviation : PNAS
Source Genre: Journal
 Creator(s):
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Publ. Info: Washington, D.C. : National Academy of Sciences
Pages: - Volume / Issue: 111 (50) Sequence Number: - Start / End Page: 18067 - 18072 Identifier: ISSN: 0027-8424
CoNE: /journals/resource/954925427230