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  Gestalt-binding of tropomyosin to actin filaments

Holmes, K. C., & Lehman, W. (2008). Gestalt-binding of tropomyosin to actin filaments. Journal of Muscle Research and Cell Motility, 29(6), 213-219. doi:10.1007/s10974-008-9157-6.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-8B65-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0000-E3A2-8
Genre: Journal Article

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JMuscleResCellMotil_29_2008_213.pdf (Any fulltext), 416KB
 
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 Creators:
Holmes, Kenneth C.1, Author              
Lehman, William, Author
Affiliations:
1Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497712              

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Free keywords: Actin, Tropomyosin, Gestalt, Gestalt-binding, Gestaltbindung, Coiled-coil, Troponin, Calcium, Muscle
 Abstract: We argue that the overall behavior of tropomyosin on F-actin cannot be easily discerned by examining thin filaments reduced to their smallest interacting units. In isolation, the individual interactions of actin and tropomyosin, by themselves, are too weak to account for the specificity of the system. Instead the association of tropomyosin on actin can only be fully explained after considering the concerted action of the entire acto-tropomyosin system. We propose that the low K ( a ) describing tropomyosin:actin interaction, when taken together with the form-fitting complementarity of tropomyosin strands on F-actin and the tendency for tropomyosin to polymerize end-to-end, make possible unique thin filament functions both locally and at higher levels of filament organization.

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Language(s): eng - English
 Dates: 2008-10-162008-12-012008-12-312008-12-01
 Publication Status: Published in print
 Pages: 7
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Degree: -

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Title: Journal of Muscle Research and Cell Motility
  Other : J. Muscle Res. Cell Motil.
Source Genre: Journal
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Publ. Info: London : Chapman and Hall
Pages: - Volume / Issue: 29 (6) Sequence Number: - Start / End Page: 213 - 219 Identifier: ISSN: 0142-4319
CoNE: /journals/resource/954925472360