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  A new fate mapping system reveals context-dependent random or clonal expansion of microglia

Tay, T. L., Mai, D., Dautzenberg, J., Fernández-Klett, F., Lin, G., Sagar, S., et al. (2017). A new fate mapping system reveals context-dependent random or clonal expansion of microglia. Nature Neuroscience, 793-803. doi:10.1038/nn.4547.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-8C22-E Version Permalink: http://hdl.handle.net/21.11116/0000-0004-EB4A-1
Genre: Journal Article

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 Creators:
Tay, Tuan Leng1, Author
Mai, Dominic1, Author
Dautzenberg, Jana1, Author
Fernández-Klett, Francisco1, Author
Lin, Gen1, Author
Sagar, Sagar2, Author
Datta, Moumita1, Author
Drougard, Anne2, Author
Stempfl, Thomas1, Author
Ardura-Fabregat, Alberto1, Author
Staszewski, Ori1, Author
Margineanu, Anca1, Author
Sporbert, Anje1, Author
Steinmetz, Lars M1, Author
Pospisilik, John Andrew2, Author              
Jung, Steffen1, Author
Priller, Josef1, Author
Grün, Dominic2, Author              
Ronneberger, Olaf1, Author
Prinz, Marco1, Author
Affiliations:
1External Organizations, ou_persistent22              
2Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, 79108 Freiburg, DE, ou_2243640              

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 Abstract: Microglia constitute a highly specialized network of tissue-resident immune cells that is important for the control of tissue homeostasis and the resolution of diseases of the CNS. Little is known about how their spatial distribution is established and maintained in vivo. Here we establish a new multicolor fluorescence fate mapping system to monitor microglial dynamics during steady state and disease. Our findings suggest that microglia establish a dense network with regional differences, and the high regional turnover rates found challenge the universal concept of microglial longevity. Microglial self-renewal under steady state conditions constitutes a stochastic process. During pathology this randomness shifts to selected clonal microglial expansion. In the resolution phase, excess disease-associated microglia are removed by a dual mechanism of cell egress and apoptosis to re-establish the stable microglial network. This study unravels the dynamic yet discrete self-organization of mature microglia in the healthy and diseased CNS.

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Language(s): eng - English
 Dates: 2017-06
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/nn.4547
 Degree: -

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Title: Nature Neuroscience
  Other : Nat. Neurosci.
Source Genre: Journal
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Publ. Info: New York, NY : Nature America Inc.
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 793 - 803 Identifier: ISSN: 1097-6256
CoNE: https://pure.mpg.de/cone/journals/resource/954925610931