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  Poly-ß-hydroxybutyrate administration during early life: effects on performance, immunity and microbial community of European sea bass yolk-sac larvae

Franke, A., Roth, O., De Schryver, P., Bayer, T., Garcia Gonzalez, L., Künzel, S., et al. (2017). Poly-ß-hydroxybutyrate administration during early life: effects on performance, immunity and microbial community of European sea bass yolk-sac larvae. Scientific Reports, 7(1): 15022. doi:10.1038/s41598-017-14785-z.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-8E39-E Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-8E3A-C
Genre: Journal Article

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 Creators:
Franke, Andrea1, Author
Roth, Olivia1, Author
De Schryver, Peter1, Author
Bayer, Till1, Author              
Garcia Gonzalez, Linsey1, Author
Künzel, Sven1, Author              
Bossier, Peter1, Author
Miest, Joanna1, Author
Clemmesen, Catriona1, Author
Affiliations:
1Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445635              

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Free keywords: Applied immunology; Gene expression; Infectious diseases; Microbiome
 Abstract: The reliable production of marine fish larvae is one of the major bottlenecks in aquaculture due to high mortalities mainly caused by infectious diseases. To evaluate if the compound poly-β-hydroxybutyrate (PHB) might be a suitable immunoprophylactic measure in fish larviculture, its capacity to improve immunity and performance in European sea bass (Dicentrarchus labrax) yolk-sac larvae was explored. PHB was applied from mouth opening onwards to stimulate the developing larval immune system at the earliest possible point in time. Larval survival, growth, microbiota composition, gene expression profiles and disease resistance were assessed. PHB administration improved larval survival and, furthermore, altered the larva-associated microbiota composition. The bacterial challenge test using pathogenic Vibrio anguillarum revealed that the larval disease resistance was not influenced by PHB. The expression profiles of 26 genes involved e.g. in the immune response showed that PHB affected the expression of the antimicrobial peptides ferritin (fer) and dicentracin (dic), however, the response to PHB was inconsistent and weaker than previously demonstrated for sea bass post-larvae. Hence, the present study highlights the need for more research focusing on the immunostimulation of different early developmental stages for gaining a more comprehensive picture and advancing a sustainable production of high quality fry.

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Language(s): eng - English
 Dates: 2017-06-232017-10-162017-11-082017
 Publication Status: Published in print
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Project name : FINEAQUA-project
Grant ID : 12212001
Funding program : Program for the Future - Economy
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Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
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Publ. Info: London, UK : Nature Publishing Group
Pages: 11 Volume / Issue: 7 (1) Sequence Number: 15022 Start / End Page: - Identifier: ISSN: 2045-2322
CoNE: /journals/resource/2045-2322