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  Genomic regions controlling shape variation in the first upper molar of the house mouse

Pallares, L. F., Ledevin, R., Pantalacci, S., Turner, L. M., Steingrimsson, E., & Renaud, S. (2017). Genomic regions controlling shape variation in the first upper molar of the house mouse. eLife, 6: e29510. doi:10.7554/eLife.29510.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-8E4E-F Version Permalink: http://hdl.handle.net/21.11116/0000-0005-1F61-C
Genre: Journal Article

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elife-29510-v2.pdf (Publisher version), 3MB
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Ethics Animal experimentation: The mice used for the association mapping were previously used in another study; details on animal experiment and ethics can be found in the original publication Turner et. al. 2012 Evolution. The mutant mice used for the validation of the gene Mitf were raised at the University of Iceland, BioMedical Center, under permit number 2013-03-01 from the Committee on Experimental Animals (Tilraunady´ranefnd).
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https://elifesciences.org/articles/29510 (Publisher version)
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Ethics Animal experimentation: The mice used for the association mapping were previously used in another study; details on animal experiment and ethics can be found in the original publication Turner et. al. 2012 Evolution. The mutant mice used for the validation of the gene Mitf were raised at the University of Iceland, BioMedical Center, under permit number 2013-03-01 from the Committee on Experimental Animals (Tilraunady´ranefnd).

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 Creators:
Pallares, Luisa F.1, Author              
Ledevin, Ronan, Author
Pantalacci, Sophie, Author
Turner, Leslie M.1, Author              
Steingrimsson, Eirikur, Author
Renaud, Sabrina, Author
Affiliations:
1Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445635              

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 Abstract: Numerous loci of large effect have been shown to underlie phenotypic variation between species. However, loci with subtle effects are presumably more frequently involved in microevolutionary processes but have rarely been discovered. We explore the genetic basis of shape variation in the first upper molar of hybrid mice between Mus musculus musculus and M. m. domesticus. We performed the first genome-wide association study for molar shape and used 3D surface morphometrics to quantify subtle variation between individuals. We show that many loci of small effect underlie phenotypic variation, and identify five genomic regions associated with tooth shape; one region contained the gene microphthalmia-associated transcription factor Mitf that has previously been associated with tooth malformations. Using a panel of five mutant laboratory strains, we show the effect of the Mitf gene on tooth shape. This is the first report of a gene causing subtle but consistent variation in tooth shape resembling variation in nature.

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Language(s): eng - English
 Dates: 2017-06-112017-10-282017-11-012017
 Publication Status: Published in print
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 Rev. Method: -
 Identifiers: DOI: 10.7554/eLife.29510
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Project name : Agence Nationale de la Recherche
Grant ID : Bigtooth (ANR-11-BSV7- 008)
Funding program : Icelandic Research Fund (152715-053)
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Title: eLife
Source Genre: Journal
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Publ. Info: Cambridge : eLife Sciences Publications
Pages: - Volume / Issue: 6 Sequence Number: e29510 Start / End Page: - Identifier: ISSN: 2050-084X
CoNE: /journals/resource/2050-084X