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  A modular approach for multifunctional polymersomes with controlled adhesive properties

Petit, J., Thomi, L., Schultze, J., Makowski, M., Negwer, I., Koynov, K., et al. (2018). A modular approach for multifunctional polymersomes with controlled adhesive properties. Soft Matter, 14(6), 894-900. doi:10.1039/C7SM01885A.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-8F57-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-6068-E
Genre: Journal Article

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 Creators:
Petit, Julien1, Author              
Thomi, Laura, Author
Schultze, Jennifer, Author
Makowski, Marcin1, Author              
Negwer, Inka, Author
Koynov, Kaloian, Author
Herminghaus, Stephan2, Author              
Wurm, Frederik, Author
Bäumchen, Oliver1, Author              
Landfester, Katharina, Author
Affiliations:
1Group Dynamics of fluid and biological interfaces, Department of Dynamics of Complex Fluids, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society, ou_2063300              
2Group Granular matter and irreversibility, Department of Dynamics of Complex Fluids, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society, ou_2063306              

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 Abstract: The bottom-up approach in synthetic biology involves the engineering of synthetic cells by designing biological and chemical building blocks, which can be combined in order to mimic cellular functions. The first step for mimicking a living cell is the design of an appropriate compartment featuring a multifunctional membrane. This is of particular interest since it allows for the selective attachment of different groups or molecules to the membrane. In this context, we report on a modular approach for polymeric vesicles, so-called polymersomes, with a multifunctional surface, namely hydroxyl, alkyne and acrylate groups. We demonstrate that the surface of the polymersome can be functionalized to facilitate imaging, via dye molecules, or to improve the specific adhesion to surfaces by using a biotin functionalization. This generally applicable multifunctionality allows for the covalent integration of various molecules in the membrane of a synthetic cell.

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Language(s): eng - English
 Dates: 2017-12-152018-02-14
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1039/C7SM01885A
 Degree: -

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Title: Soft Matter
Source Genre: Journal
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Publ. Info: -
Pages: 7 Volume / Issue: 14 (6) Sequence Number: - Start / End Page: 894 - 900 Identifier: ISSN: 1744-683X