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  Ectopic expression of Pax4 in pancreatic δ cells results in β-like cell neogenesis

Druelle, N., Vieira, A., Shabro, A., Courtney, M., Mondin, M., Rekima, S., et al. (2017). Ectopic expression of Pax4 in pancreatic δ cells results in β-like cell neogenesis. The Journal of Cell Biology, 216(12), 4299-4311. doi:10.1083/jcb.201704044.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-8F9E-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-1EC1-4
Genre: Journal Article

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 Creators:
Druelle, N., Author
Vieira, A., Author
Shabro, A., Author
Courtney, M., Author
Mondin, M., Author
Rekima, S., Author
Napolitano, T., Author
Silvano, S., Author
Navarro-Sanz, S., Author
Hadzic, B., Author
Avolio, F., Author
Rassoulzadegan, M., Author
Schmid, H. A., Author
Mansouri, A.1, Author              
Collombat, P., Author
Affiliations:
1Research Group of Molecular Cell Differentiation, MPI for biophysical chemistry, Max Planck Society, ou_578588              

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 Abstract: The recent demonstration that pancreatic a cells can be continuously regenerated and converted into beta-like cells upon ectopic expression of Pax4 opened new avenues of research in the endocrine cell differentiation and diabetes fields. To determine whether such plasticity was also shared by delta cells, we generated and characterized transgenic animals that express Pax4 specifically in somatostatin-expressing cells. We demonstrate that the ectopic expression of Pax4 in d cells is sufficient to induce their conversion into functional beta-like cells. Importantly, this conversion induces compensatory mechanisms involving the reactivation of endocrine developmental processes that result in dramatic beta-like cell hyperplasia. Importantly, these beta-like cells are functional and can partly reverse the consequences of chemically induced diabetes.

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Language(s): eng - English
 Dates: 2017-10-122017-12-04
 Publication Status: Published in print
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1083/jcb.201704044
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Title: The Journal of Cell Biology
Source Genre: Journal
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Pages: - Volume / Issue: 216 (12) Sequence Number: - Start / End Page: 4299 - 4311 Identifier: -