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  Faecal microbiota composition associates with abdominal pain in the general population

Hadizadeh, F., Bonfiglio, F., Belheouane, M., Vallier, M., Sauer, S., Bang, C., et al. (2018). Faecal microbiota composition associates with abdominal pain in the general population. Gut, 67(4), 778-779. doi:10.1136/gutjnl-2017-314792.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-9009-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-F499-D
Genre: Journal Article

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 Creators:
Hadizadeh, Fatemeh, Author
Bonfiglio, Ferdinando, Author
Belheouane, Meriem1, Author              
Vallier, Marie1, Author              
Sauer, Sascha, Author
Bang, Corinna, Author
Bujanda, Luis, Author
Andreasson, Anna, Author
Agreus, Lars, Author
Engstrand, Lars, Author
Talley, Nicholas J, Author
Rafter, Joseph, Author
Baines, John F.1, Author              
Walter, Susanna, Author
Franke, Andre, Author
D'Amato, Mauro, Author
Affiliations:
1Guest Group Evolutionary Genomics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445638              

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 Abstract: We read with great interest the recent communication by Simrén et al,1 reporting a correlation between visceral hypersensitivity and GI symptom severity in functional GI disorders (FGID). Previously, it has been shown that visceral hypersensitivity can be modulated or even induced in animal models, by altering the composition of their gut microbiota with antibiotics or faecal transplantation from IBS donors.2 3 Hence, while a direct link between gut microbiota composition and visceral pain may need to be conclusively established, this holds great potential for translational exploitation in the treatment of IBS and other FGID. Thus far, the potential association between microbiota and abdominal pain in humans has only been investigated in one study that included 15 individuals.4 For this purpose, we studied 159 individuals (average age 59.1, 39.6% men) from the Swedish Population-based Colonoscopy (PopCol) cohort, previously described and with faecal microbiota 16S sequencing data and daily recordings of abdominal pain (number of episodes, duration and intensity) collected over the same period (7.41±7.91 days).5–7 Among these, 52 individuals (assigned to the case group) reported at least one episode …

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Language(s): eng - English
 Dates: 2017-07-042017-07-132017-08-012018-04
 Publication Status: Published in print
 Pages: -
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 Identifiers: DOI: 10.1136/gutjnl-2017-314792
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Project name : Supported by funds from the Swedish Research Council (“Vetenskapsradet”) to MD and the European Union Seventh Framework Program (FP7/2007-2013, grant number 262055, ESGI) to MD, SS and AF; Iranian ministry of health and medical education to FH; FH is a member of the Research Training Group (RTG) 1743 “Genes, Environment and Inflammation”, funded by German Research Foundation (DFG).
Grant ID : 262055
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Title: Gut
  Other : Gut
Source Genre: Journal
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Publ. Info: London : BMJ Publishing Group
Pages: - Volume / Issue: 67 (4) Sequence Number: - Start / End Page: 778 - 779 Identifier: Other: 1468-3288
ISSN: 0017-5749
CoNE: https://pure.mpg.de/cone/journals/resource/954925402606