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  Stimulating neural plasticity with real-time fMRI neurofeedback in Huntington's disease: A proof of concept study

Papoutsi, M., Weiskopf, N., Langbehn, D., Reilmann, R., Rees, G., & Tabrizi, S. J. (2018). Stimulating neural plasticity with real-time fMRI neurofeedback in Huntington's disease: A proof of concept study. Human Brain Mapping, 39(3), 1339-1353. doi:10.1002/hbm.23921.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-90A5-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-4E98-9
Genre: Journal Article

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 Creators:
Papoutsi, Marina1, Author
Weiskopf, Nikolaus2, 3, Author              
Langbehn, Douglas4, Author
Reilmann, Ralph5, 6, Author
Rees, Geraint3, 7, Author
Tabrizi, Sarah J.1, Author
Affiliations:
1UCL Huntington's Disease Centre, Institute of Neurology, University College London, United Kingdom, ou_persistent22              
2Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
3Wellcome Trust Centre for Neuroimaging, University College London, United Kingdom, ou_persistent22              
4Carver College of Medicine, University of Iowa, Iowa City, IA, USA, ou_persistent22              
5Department of Radiology, Münster University, Germany, ou_persistent22              
6Hertie-Institute for Clinical Brain Research, Eberhard Karls University Tübingen, Germany, ou_persistent22              
7Institute of Cognitive Neuroscience, University College London, United Kingdom, ou_persistent22              

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Free keywords: Huntington's disease; Brain training; Neurodegenerative diseases; Neurofeedback training; Neuroplasticity; Real-time fMRI
 Abstract: Novel methods that stimulate neuroplasticity are increasingly being studied to treat neurological and psychiatric conditions. We sought to determine whether real-time fMRI neurofeedback training is feasible in Huntington's disease (HD), and assess any factors that contribute to its effectiveness. In this proof-of-concept study, we used this technique to train 10 patients with HD to volitionally regulate the activity of their supplementary motor area (SMA). We collected detailed behavioral and neuroimaging data before and after training to examine changes of brain function and structure, and cognitive and motor performance. We found that patients overall learned to increase activity of the target region during training with variable effects on cognitive and motor behavior. Improved cognitive and motor performance after training predicted increases in pre-SMA grey matter volume, fMRI activity in the left putamen, and increased SMA-left putamen functional connectivity. Although we did not directly target the putamen and corticostriatal connectivity during neurofeedback training, our results suggest that training the SMA can lead to regulation of associated networks with beneficial effects in behavior. We conclude that neurofeedback training can induce plasticity in patients with Huntington's disease despite the presence of neurodegeneration, and the effects of training a single region may engage other regions and circuits implicated in disease pathology.

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Language(s): eng - English
 Dates: 2017-11-142017-06-052017-12-072017-12-132018-03
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/hbm.23921
PMC: PMC5838530
PMID: 29239063
Other: Epub 2017
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Project name : -
Grant ID : 376
Funding program : -
Funding organization : European Huntington's Disease Network (EHDN)
Project name : -
Grant ID : MR‐L012936‐1
Funding program : MRC Developmental Pathway Funding Scheme
Funding organization : Medical Research Council (MRC)

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Title: Human Brain Mapping
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 39 (3) Sequence Number: - Start / End Page: 1339 - 1353 Identifier: ISSN: 1065-9471
CoNE: https://pure.mpg.de/cone/journals/resource/954925601686