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  Metabolic Instruction of Immunity

Buck, M., Sowell, R. T., Kaech, S. M., & Pearce, E. L. (2017). Metabolic Instruction of Immunity. Cell, 169, 570-586. doi:10.1016/j.cell.2017.04.004.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0000-BF8E-A Version Permalink: https://hdl.handle.net/21.11116/0000-0008-96DA-9
Genre: Journal Article

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Buck et al..pdf (Publisher version), 3MB
 
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https://www.sciencedirect.com/science/article/pii/S0092867417304166?via%3Dihub (Publisher version)
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 Creators:
Buck, Michael1, Author
Sowell, Ryan T.2, Author
Kaech, Susan M.2, Author
Pearce, Erika L.1, Author           
Affiliations:
1Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, 79108 Freiburg, DE, ou_2243640              
2Department of Immunobiology, Yale University School of Medicine, CT, USA, ou_persistent22              

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 Abstract: Choices have consequences. Immune cells survey and migrate throughout the body and sometimes take residence in niche environments with distinct communities of cells, extracellular matrix, and nutrients that may differ from those in which they matured. Imbedded in immune cell physiology are metabolic pathways and metabolites that not only provide energy and substrates for growth and survival, but also instruct effector functions, differentiation, and gene expression. This review of immunometabolism will reference the most recent literature to cover the choices that environments impose on the metabolism and function of immune cells and highlight their consequences during homeostasis and disease.

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Language(s): eng - English
 Dates: 2017-05-04
 Publication Status: Issued
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.cell.2017.04.004
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Title: Cell
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 169 Sequence Number: - Start / End Page: 570 - 586 Identifier: ISSN: 0092-8674
CoNE: https://pure.mpg.de/cone/journals/resource/954925463183