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  Low frequency transcranial electrical stimulation does not entrain sleep rhythms measured by human intracranial recordings

Lafon, B., Henin, S., Huang, Y., Friedman, D., Melloni, L., Thesen, T., et al. (2017). Low frequency transcranial electrical stimulation does not entrain sleep rhythms measured by human intracranial recordings. Nature Communications, 8: 1199. doi:10.1038/s41467-017-01045-x.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-929A-8 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-929B-6
Genre: Journal Article

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 Creators:
Lafon, Belen1, Author
Henin, Simon2, 3, Author
Huang, Yu1, Author
Friedman, Daniel2, 3, Author
Melloni, Lucia2, 3, 4, Author              
Thesen, Thomas3, 5, Author
Doyle, Werner2, 6, Author
Buzsáki, György3, 7, Author
Devinsky, Orrin2, 3, Author
Parra, Lucas C.1, Author
Liu, Anli A.2, 3, Author
Affiliations:
1Department of Biomedical Engineering, City College of New York, 160 Convent Ave, New York, NY, 10031, USA, ou_persistent22              
2New York University Comprehensive Epilepsy Center , 223 East 34th Street, New York, NY, 10016, USA, ou_persistent22              
3Department of Neurology, New York University School of Medicine , 240 East 38th St, 20th Floor, New York, NY, 10016, USA, ou_persistent22              
4Department of Neuroscience, Max Planck Institute for Empirical Aesthetics, Max Planck Society, ou_2421697              
5Department of Physiology and Neuroscience, St. George’s University , St. George’s, Grenada, ou_persistent22              
6Department of Neurosurgery NYU School of Medicine, 530 1st Avenue, Suite 7W, New York, NY, 10016, USA, ou_persistent22              
7New York University Neuroscience Institute , 450 East 29th St, New York, NY, 10016, USA, ou_persistent22              

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Free keywords: Consolidation; Electroencephalography – EEG; Epilepsy; Non-REM sleep
 Abstract: Transcranial electrical stimulation has widespread clinical and research applications, yet its effect on ongoing neural activity in humans is not well established. Previous reports argue that transcranial alternating current stimulation (tACS) can entrain and enhance neural rhythms related to memory, but the evidence from non-invasive recordings has remained inconclusive. Here, we measure endogenous spindle and theta activity intracranially in humans during low-frequency tACS and find no stable entrainment of spindle power during non-REM sleep, nor of theta power during resting wakefulness. As positive controls, we find robust entrainment of spindle activity to endogenous slow-wave activity in 66% of electrodes as well as entrainment to rhythmic noise-burst acoustic stimulation in 14% of electrodes. We conclude that low-frequency tACS at common stimulation intensities neither acutely modulates spindle activity during sleep nor theta activity during waking rest, likely because of the attenuated electrical fields reaching the cortical surface.

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Language(s): eng - English
 Dates: 2017-06-032017-08-152017-10-31
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/s41467-017-01045-x
 Degree: -

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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 8 Sequence Number: 1199 Start / End Page: - Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723