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  A model of individualized canonical microcircuits supporting cognitive operations

Kunze, T., Peterson, A. D. H., Haueisen, J., & Knösche, T. R. (2017). A model of individualized canonical microcircuits supporting cognitive operations. PLoS One, 12(12): e0188003. doi:10.1371/journal.pone.0188003.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-96EB-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-BD3B-7
Genre: Journal Article

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 Creators:
Kunze, Tim1, 2, Author              
Peterson, Andre D. H.3, Author
Haueisen, Jens1, 2, Author
Knösche, Thomas R.1, Author              
Affiliations:
1Methods and Development Group MEG and EEG - Cortical Networks and Cognitive Functions, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_2205650              
2Institute for Biomedical Engineering and Informatics, TU Ilmenau, Germany, ou_persistent22              
3Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Australia, ou_persistent22              

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 Abstract: Major cognitive functions such as language, memory, and decision-making are thought to rely on distributed networks of a large number of basic elements, called canonical microcircuits. In this theoretical study we propose a novel canonical microcircuit model and find that it supports two basic computational operations: a gating mechanism and working memory. By means of bifurcation analysis we systematically investigate the dynamical behavior of the canonical microcircuit with respect to parameters that govern the local network balance, that is, the relationship between excitation and inhibition, and key intrinsic feedback architectures of canonical microcircuits. We relate the local behavior of the canonical microcircuit to cognitive processing and demonstrate how a network of interacting canonical microcircuits enables the establishment of spatiotemporal sequences in the context of syntax parsing during sentence comprehension. This study provides a framework for using individualized canonical microcircuits for the construction of biologically realistic networks supporting cognitive operations.

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Language(s): eng - English
 Dates: 2017-05-292017-10-252017-12-04
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1371/journal.pone.0188003
PMID: 29200435
PMC: PMC5714354
Other: eCollection 2017
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Funding organization : Max Planck Society
Project name : -
Grant ID : 57061157
Funding program : DAAD-Go8-Germany joint research scheme
Funding organization : Deutscher Akademischer Austauschdienst e.V.
Project name : -
Grant ID : -
Funding program : Sir John Eccles Research Fellowship
Funding organization : The John Curtin School of Medical Research
Project name : Erforschung von neuen trockenen Elektrodentechnologien, neuen Quanten- und optisch gepumpten Magnetometern und die Entwicklung von neuartigen Messinstrumenten / BASIs
Grant ID : 2015 FGR 0085
Funding program : -
Funding organization : Thuringian Ministry of Science

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Title: PLoS One
Source Genre: Journal
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Publ. Info: San Francisco, CA : Public Library of Science
Pages: - Volume / Issue: 12 (12) Sequence Number: e0188003 Start / End Page: - Identifier: ISSN: 1932-6203
CoNE: /journals/resource/1000000000277850