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  Perturbation of whole-brain dynamics in silico reveals mechanistic differences between brain states

Deco, G., Cabral, J., Saenger, V. M., Boly, M., Tagliazucchi, E., Laufs, H., et al. (2018). Perturbation of whole-brain dynamics in silico reveals mechanistic differences between brain states. NeuroImage, 169, 46-56. doi:10.1016/j.neuroimage.2017.12.009.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-98D9-A Version Permalink: http://hdl.handle.net/21.11116/0000-0003-A47A-B
Genre: Journal Article

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 Creators:
Deco, Gustavo1, 2, 3, 4, Author              
Cabral, Joana5, 6, 7, Author
Saenger, Victor M.1, Author
Boly, Melanie8, 9, Author
Tagliazucchi, Enzo10, 11, Author
Laufs, Helmut11, 12, Author
Van Someren, Eus13, 14, Author
Jobst, Beatrice1, Author
Stevner, Angus5, 6, Author
Kringelbach, Morten L.5, 6, 7, 15, Author
Affiliations:
1Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
2Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
3Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
4School of Psychological Sciences, Monash University, Melbourne, Australia, ou_persistent22              
5Department of Psychiatry, University of Oxford, United Kingdom, ou_persistent22              
6Center for Music in the Brain, Aarhus University, the Netherlands, ou_persistent22              
7ICVS - Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga, Portugal, ou_persistent22              
8Department of Psychiatry, University of Wisconsin, Madison, WI, USA, ou_persistent22              
9Department of Neurology, University of Wisconsin, Madison, WI, USA, ou_persistent22              
10Institute for Medical Psychology, Christian Albrecht University Kiel, Germany, ou_persistent22              
11Brain Imaging Centre, Goethe University, Frankfurt, Germany, ou_persistent22              
12Department of Neurology, Christian Albrecht University Kiel, Germany, ou_persistent22              
13Department of Sleep and Cognition, The Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands, ou_persistent22              
14Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), VU University Medical Center, Amsterdam, the Netherlands, ou_persistent22              
15Institut d’études avancées de Paris, France, ou_persistent22              

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Free keywords: Brain state; Sleep; Whole brain modeling; Perturbation
 Abstract: Human neuroimaging research has revealed that wakefulness and sleep involve very different activity patterns. Yet, it is not clear why brain states differ in their dynamical complexity, e.g. in the level of integration and segregation across brain networks over time. Here, we investigate the mechanisms underlying the dynamical stability of brain states using a novel off-line in silico perturbation protocol. We first adjust a whole-brain computational model to the basal dynamics of wakefulness and deep sleep recorded with fMRI in two independent human fMRI datasets. Then, the models of sleep and awake brain states are perturbed using two distinct multifocal protocols either promoting or disrupting synchronization in randomly selected brain areas. Once perturbation is halted, we use a novel measure, the Perturbative Integration Latency Index (PILI), to evaluate the recovery back to baseline. We find a clear distinction between models, consistently showing larger PILI in wakefulness than in deep sleep, corroborating previous experimental findings. In the models, larger recoveries are associated to a critical slowing down induced by a shift in the model's operation point, indicating that the awake brain operates further from a stable equilibrium than deep sleep. This novel approach opens up for a new level of artificial perturbative studies unconstrained by ethical limitations allowing for a deeper investigation of the dynamical properties of different brain states.

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Language(s): eng - English
 Dates: 2017-11-272017-06-012017-12-042017-12-072018-04-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2017.12.009
PMID: 29225066
Other: Epub 2017
 Degree: -

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Project name : The Dynamical and Structural Basis of Human Mind Complexity: Segregation and Integration of Information and Processing in the Brain / DYSTRUCTURE
Grant ID : 295129
Funding program : Horizon 2020
Funding organization : European Commission (EC)
Project name : Brain-inspired multiscale computation in neuromorphic hybrid systems / BRAINSCALES
Grant ID : 269921
Funding program : Funding Programme 7
Funding organization : European Commission (EC)
Project name : The plasticity of parental caregiving: characterizing the brain mechanisms underlying normal and disrupted development of parenting / CAREGIVING
Grant ID : 615539
Funding program : Funding Programme 7
Funding organization : European Commission (EC)
Project name : -
Grant ID : DNRF117
Funding program : -
Funding organization : Danish National Research Foundation
Project name : Frontiers of technology for theranostics of cancer, metabolic and neurodegenerative diseases
Grant ID : NORTE-01-0145-FEDER-000023
Funding program : Northern Portugal Regional Operational Programme (NORTE 2020)
Funding organization : CCDR-N
Project name : -
Grant ID : -
Funding program : European Regional Development Fund
Funding organization : European Commission (EC)

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Title: NeuroImage
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 169 Sequence Number: - Start / End Page: 46 - 56 Identifier: ISSN: 1053-8119
CoNE: /journals/resource/954922650166