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  A completely reimplemented MPI Bioinformatics Toolkit with a new HHpred server at its core.

Zimmermann, L., Stephens, A., Nam, S. Z., Rau, D., Kübler, J., Lozajic, M., et al. (2018). A completely reimplemented MPI Bioinformatics Toolkit with a new HHpred server at its core. Journal of Molecular Biology, 430(15), 2237-2243. doi:10.1016/j.jmb.2017.12.007.

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Zimmermann, L., Autor
Stephens, A., Autor
Nam, S. Z., Autor
Rau, D., Autor
Kübler , J., Autor
Lozajic, M., Autor
Gabler, F., Autor
Söding, J.1, Autor           
Lupas, A. N., Autor
Alva, V., Autor
Affiliations:
1Research Group of Computational Biology, MPI for Biophysical Chemistry, Max Planck Society, ou_1933286              

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Schlagwörter: MPI Bioinformatics Toolkit; HHpred; HHblits; Structure prediction; Remote homology detection
 Zusammenfassung: The MPI Bioinformatics Toolkit (https://toolkit.tuebingen.mpg.de) is a free, one-stop web service for protein bioinformatic analysis. It currently offers 34 interconnected external and in-house tools, whose functionality covers sequence similarity searching, alignment construction, detection of sequence features, structure prediction, and sequence classification. This breadth has made the Toolkit an important resource for experimental biology and for teaching bioinformatic inquiry. Recently, we replaced the first version of the Toolkit, which was released in 2005 and had served around 2.5 million queries, with an entirely new version, focusing on improved features for the comprehensive analysis of proteins, as well as on promoting teaching. For instance, our popular remote homology detection server, HHpred, now allows pairwise comparison of two sequences or alignments and offers additional profile HMMs for several model organisms and domain databases. Here, we introduce the new version of our Toolkit and its application to the analysis of proteins.

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Sprache(n): eng - English
 Datum: 2017-12-162018-07-20
 Publikationsstatus: Erschienen
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 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1016/j.jmb.2017.12.007
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Titel: Journal of Molecular Biology
Genre der Quelle: Zeitschrift
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Seiten: - Band / Heft: 430 (15) Artikelnummer: - Start- / Endseite: 2237 - 2243 Identifikator: -