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  High-resolution CBV-fMRI allows mapping of laminar activity and connectivity of cortical input and output in human M1

Huber, L., Handwerker, D. A., Jangraw, D. C., Chen, G., Hall, A., Stüber, C., et al. (2017). High-resolution CBV-fMRI allows mapping of laminar activity and connectivity of cortical input and output in human M1. Neuron, 96(6), 1253-1263. doi:10.1016/j.neuron.2017.11.005.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-9BD2-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-BD0F-9
Genre: Journal Article

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 Creators:
Huber, Laurentius1, Author
Handwerker, Daniel A.1, Author
Jangraw, David C.1, Author
Chen, Gang1, Author
Hall, Andrew1, Author
Stüber, Carsten2, 3, Author              
Gonzalez-Castillo, Javier1, Author
Ivanov, Dimo4, Author
Marrett, Sean1, Author
Guidi, Maria5, Author              
Goense, Jozien6, Author
Poser, Benedikt A.4, Author
Bandettini, Peter A.1, Author
Affiliations:
1National Institutes of Health, Bethesda, MD, USA, ou_persistent22              
2Department of Radiology, Weill Cornell Medical College, New York, NY, USA, ou_persistent22              
3Department of Neurology, Yale School of Medicine, New Haven, CT, USA, ou_persistent22              
4Maastricht Brain Imaging Center (M-BIC), Maastricht University, the Netherlands, ou_persistent22              
5Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
6Institute of Neuroscience and Psychology, University of Glasgow, United Kingdom, ou_persistent22              

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Free keywords: Layer fMRI; fMRI; Cortical layers; Neurovascular coupling; VASO; BOLD
 Abstract: Layer-dependent fMRI allows measurements of information flow in cortical circuits, as afferent and efferent connections terminate in different cortical layers. However, it is unknown to what level human fMRI is specific and sensitive enough to reveal directional functional activity across layers. To answer this question, we developed acquisition and analysis methods for blood-oxygen-level-dependent (BOLD) and cerebral-blood-volume (CBV)-based laminar fMRI and used these to discriminate four different tasks in the human motor cortex (M1). In agreement with anatomical data from animal studies, we found evidence for somatosensory and premotor input in superficial layers of M1 and for cortico-spinal motor output in deep layers. Laminar resting-state fMRI showed directional functional connectivity of M1 with somatosensory and premotor areas. Our findings demonstrate that CBV-fMRI can be used to investigate cortical activity in humans with unprecedented detail, allowing investigations of information flow between brain regions and outperforming conventional BOLD results that are often buried under vascular biases.

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Language(s): eng - English
 Dates: 2017-09-252017-06-052017-11-022017-12-072017-12-20
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neuron.2017.11.005
PMID: 29224727
PMC: PMC5739950
Other: Epub 2017
 Degree: -

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Project name : Ultra-High Field Magnetic Resonance Imaging / HIMR
Grant ID : 316716
Funding program : Funding Programme
Funding organization : European Commission (EC)
Project name : -
Grant ID : ZIA-MH002783
Funding program : Intramural Research Program
Funding organization : National Institutes of Health (NIH)

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Title: Neuron
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 96 (6) Sequence Number: - Start / End Page: 1253 - 1263 Identifier: ISSN: 0896-6273
CoNE: https://pure.mpg.de/cone/journals/resource/954925560565